Many common variants have been associated with hematological traits, but identification of
causal genes and pathways has proven challenging. We performed a genome-wide …

Long-range interactions between regulatory elements and gene promoters play key roles in
transcriptional regulation. The vast majority of interactions are uncharted, constituting a …

Introduction Monocytes circulate in the bloodstream for up to 3 to 5 days. Concomitantly,
immunological imprinting of either tolerance (immunosuppression) or trained immunity (innate …

Most patients with rare diseases do not receive a molecular diagnosis and the aetiological
variants and causative genes for more than half such disorders remain to be discovered 1 . …

Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high-…

The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …

Background : Inflammation drives atherosclerotic plaque rupture. Although inflammation can
be measured using fluorine-18-labeled fluorodeoxyglucose positron emission tomography (…

Alcohol drinking has been associated with increased blood pressure in epidemiological
studies. We conducted a meta-analysis of randomized controlled trials to assess the effects of …

We present a new modification of the Newton’s method which produces iterative methods
with order of convergence three. A general error analysis providing the higher order of …

Introduction Blood production in humans culminates in the daily release of around 10 11
cells into the circulation, mainly platelets and red blood cells. All blood cells originate from a …