Onset of differentiation is post-transcriptionally controlled in adult neural stem cells

…, Y Dang, GS Gülcüler Balta, G Kalamakis, M Göpferich… - Nature, 2019 - nature.com
Whether post-transcriptional regulation of gene expression controls differentiation of stem
cells for tissue renewal remains unknown. Quiescent stem cells exhibit a low level of protein …

Matrices and scaffolds for protein delivery in tissue engineering

JK Tessmar, AM Göpferich - Advanced drug delivery reviews, 2007 - Elsevier
The tissue engineering of functional tissues depends on the development of suitable scaffolds
to support three dimensional cell growth. To improve the properties of the scaffolds, many …

Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle

…, M Göpferich, A Jolly, K Volk, M Zumwinkel… - EMBO Molecular …, 2023 - embopress.org
Stem cells show intrinsic interferon signalling, which protects them from viral infections at all
ages. In the ageing brain, interferon signalling also reduces the ability of stem cells to …

Customized PEG‐derived copolymers for tissue‐engineering applications

JK Tessmar, AM Göpferich - Macromolecular bioscience, 2007 - Wiley Online Library
PEG‐containing copolymers play a prominent role as biomaterials for different applications
ranging from drug delivery to tissue engineering. These custom‐designed materials offer …

Enzymatically degradable poly (ethylene glycol) based hydrogels for adipose tissue engineering

…, AK Seitz, JKV Teßmar, T Blunk, AM Göpferich - Biomaterials, 2010 - Elsevier
Adipose tissue engineering requires biomaterials that promote the differentiation of seeded
adipocytes. Here, we report on the development and characterization of in situ forming, poly(…

Single cell 3'UTR analysis identifies changes in alternative polyadenylation throughout neuronal differentiation and in autism

M Göpferich, NO George, AD Muelas, A Bizyn… - BioRxiv, 2020 - biorxiv.org
… 28908) in 0.1 M DPBS for 5 min at RT with soft agitation. Crosslinking was stopped with
0.25 M glycine for 4 min and washed twice with ice-cold DPBS. Pellets were processed as …

Cyclodextrin based hydrogels: Inclusion complex formation and micellization of adamantane and cholesterol grafted polymers

…, FP Brandl, GM Zayed, JK Teßmar, AM Göpferich - Polymer, 2011 - Elsevier
Inclusion complex formation between β-cyclodextrin (β-CD) and suitable guest molecules
has frequently been exploited to design self-assembled polymer networks. In this paper, we …

[HTML][HTML] Regulation of adult CNS axonal regeneration by the post-transcriptional regulator Cpeb1

…, S Limpert, M Göpferich, M Zschaetzsch… - Frontiers in Molecular …, 2018 - frontiersin.org
Adult mammalian central nervous system (CNS) neurons are unable to regenerate following
axonal injury, leading to permanent functional impairments. Yet, the reasons underlying this …

Polyethylenimine-based non-viral gene delivery systems

U Lungwitz, M Breunig, T Blunk, A Göpferich - European Journal of …, 2005 - Elsevier
Gene therapy has become a promising strategy for the treatment of many inheritable or acquired
diseases that are currently considered incurable. Non-viral vectors have attracted great …

Polymer bulk erosion

A Göpferich - Macromolecules, 1997 - ACS Publications
… The samples were eroded in 10 mL of 0.1 M phosphate buffer, pH 7.4, which was changed
regularly. Prior to the determination of mass loss, solid samples were vacuum dried for …