Transposable Elements (TEs) are mobile genetic elements whose sequences constitute
nearly half of the human genome. Each TE copy can be present in hundreds to thousands of …

The genetic mechanisms underlying the expansion in size and complexity of the human
brain remain poorly understood. Long interspersed nuclear element–1 (L1) retrotransposons …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the progressive loss of motor neurons. While several pathogenic mutations have been …

… To find the optimal value of clusters, k, we minimize the residuals between the original
full gene expression matrix (N×M) and the two factorized matrices (N×k)(k×M) while …

Accumulation of cytoplasmic inclusions of TAR-DNA binding protein 43 (TDP-43) is seen in
both neurons and glia in a range of neurodegenerative disorders, including amyotrophic …

Next-generation sequencing approaches have fundamentally changed the types of questions
that can be asked about gene function and regulation. With the goal of approaching truly …

Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a
robust, but poorly understood, neuroinflammatory response that contributes to the long-term …

Endogenous retroviruses (ERVs) are remnants of ancient parasitic infections and comprise
sizable portions of most genomes. Although epigenetic mechanisms silence most ERVs by …

The current academic culture facing women in science, technology, engineering, and math (STEM)
fields in the United States has sparked the formation of grassroots advocacy groups …

Nuclear clearance and cytoplasmic aggregation of the RNA-binding protein TDP-43 are
observed in many neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) …