Genome-wide association studies of neurological diseases have identified thousands of
variants associated with disease phenotypes. However, most of these variants do not alter …

A major challenge in human genetics is to identify the molecular mechanisms of trait-associated
and disease-associated variants. To achieve this, quantitative trait locus (QTL) mapping …

Long non-coding RNA (lncRNA) genes have well-established and important impacts on
molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a …

… work and members of the M. Bassik laboratory for experimental advice. We also thank R. …
Montgomery laboratory for general guidance and feedback on this work and members of the M. …

To the Editor—Genome-wide association studies (GWAS) are rapidly expanding the catalog
of trait-and disease-associated variants. With increasing cohort size and phenotyping, …

Gene co-expression networks capture biologically important patterns in gene expression
data, enabling functional analyses of genes, discovery of biomarkers, and interpretation of …

Coronary artery disease (CAD) is the leading cause of death globally. Genome-wide association
studies (GWASs) have identified more than 95 independent loci that influence CAD risk…

Background Population structure among study subjects may confound genetic association
studies, and lack of proper correction can lead to spurious findings. The Genotype-Tissue …

Induced pluripotent stem cells (iPSCs) are an established cellular system to study the impact
of genetic variants in derived cell types and developmental contexts. However, in their …

The impact of inherited genetic variation on gene expression in humans is well-established.
The majority of known expression quantitative trait loci (eQTLs) impact expression of local …