Cerebral blood flow (CBF) reductions in Alzheimer’s disease patients and related mouse
models have been recognized for decades, but the underlying mechanisms and resulting …

Obesity is linked to increased risk for and severity of Alzheimer’s disease (AD). Cerebral
blood flow (CBF) reductions are an early feature of AD and are also linked to obesity. We …

The health and function of tissue rely on its vasculature network to provide reliable blood
perfusion. Volumetric imaging approaches, such as multiphoton microscopy, are able to …

Despite the key role of the capillaries in neurovascular function, a thorough characterization
of cerebral capillary network properties is currently lacking. Here, we define a range of …

Alzheimer’s disease is associated with a 20–30% reduction in cerebral blood flow. In the
APP/PS1 mouse model of Alzheimer’s disease, inhibiting neutrophil adhesion using an …

Increased incidence of stalled capillary blood flow caused by adhesion of leucocytes to the
brain microvascular endothelium leads to a 17% reduction of cerebral blood flow and …

Fracture damage mechanisms are some of the most significant causes of structural failure in
asphalt mixtures. Ye t much research is still needed to understand properly the fracture …

The clinical evidence suggests that cognitive disorders are associated with vasculature
dysfunction and decreased blood flow in the brain. Hence, a functional understanding of the …

Exercise exerts a beneficial effect on the major pathological and clinical symptoms associated
with Alzheimer’s disease in humans and mouse models of the disease. While numerous …

This paper describes the development and validation of a virtual microstructure generator
that can be used to fabricate a virtual, two-dimensional (2D) microstructure of particle-…