[HTML][HTML] Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production

X Wu, EAB Azizan, E Goodchild, S Garg, M Hagiyama… - Nature …, 2023 - nature.com
Aldosterone-producing adenomas (APAs) are the commonest curable cause of hypertension.
Most have gain-of-function somatic mutations of ion channels or transporters. Herein we …

Nerve-mast cell and smooth muscle-mast cell interaction mediated by cell adhesion molecule-1, CADM1

A Ito, M Hagiyama, J Oonuma - Journal of Smooth Muscle Research, 2008 - jstage.jst.go.jp
Mast cells are a native composer of connective tissue of the skin dermis and intestinal and
respiratory mucosa. Independent lines of accumulated evidence indicate the existence of an …

[HTML][HTML] Gefitinib and luteolin cause growth arrest of human prostate cancer PC-3 cells via inhibition of cyclin G-associated kinase and induction of miR-630

…, A Okamoto, H Tabara, T Inoue, M Hagiyama… - PloS one, 2014 - journals.plos.org
Cyclin G-associated kinase (GAK), a key player in clathrin-mediated membrane trafficking,
is overexpressed in various cancer cells. Here, we report that GAK expression is positively …

Upregulation of notch2 and six1 is associated with progression of early-stage lung adenocarcinoma and a more aggressive phenotype at advanced stages

T Mimae, M Okada, M Hagiyama, Y Miyata… - Clinical Cancer …, 2012 - AACR
Purpose: Lung adenocarcinoma often manifests as tumors with mainly lepidic growth. The
size of invasive foci determines a diagnosis of in situ, minimally invasive adenocarcinoma, or …

Prolidase deficiency: Its dermatological manifestations and some additional biochemical studies

…, S Umemura, Y Yamamoto, M Hagiyama… - Archives of …, 1979 - jamanetwork.com
… Reaction mixture contained 0.2 ml ofenzyme solution and0.5 ml of substrate solution in
0.1M tris … drin-acetic acid (500 mg ninhydrin, 5 ml glacial acetic acid, and 100 ml of m-butyl …

[HTML][HTML] α-Fetoprotein-Producing Endometrial Carcinoma Is Associated With Fetal Gut-Like and/or Hepatoid Morphology, Lymphovascular Infiltration, TP53 …

…, N Shiraishi, M Hagiyama, T Satou, M Matsuki… - Frontiers in …, 2021 - frontiersin.org
The clinicopathological, immunohistochemical, and molecular characteristics of α-fetoprotein
(AFP)-producing endometrial carcinoma (AFP+ EC) are poorly understood. From 284 …

Noncontact estimation of intercellular breaking force using a femtosecond laser impulse quantified by atomic force microscopy

Y Hosokawa, M Hagiyama, T Iino… - Proceedings of the …, 2011 - National Acad Sciences
When a femtosecond laser pulse (fsLP) is focused through an objective lens into a culture
medium, an impulsive force (fsLP-IF) is generated that propagates from the laser focal point (O …

[HTML][HTML] Renal ADAM10 and 17: their physiological and medical meanings

T Kato, M Hagiyama, A Ito - Frontiers in cell and developmental …, 2018 - frontiersin.org
A disintegrin and metalloproteinases (ADAMs) are a Zn 2+ -dependent transmembrane and
secreted metalloprotease superfamily, so-called “molecular scissors,” and they consist of an …

Cell Adhesion Molecule 1 Is a Novel Pancreatic–Islet Cell Adhesion Molecule That Mediates Nerve–Islet Cell Interactions

…, M Hagiyama, K Hamaguchi, M Nakanishi, M Masuda… - Gastroenterology, 2008 - Elsevier
BACKGROUND & AIMS: Cell adhesion molecule 1 (CADM1), formerly called tumor suppressor
in lung cancer-1 or nectin-like molecule-2, mediates nerve–mast cell attachment and …

Enhanced nerve–mast cell interaction by a neuronal short isoform of cell adhesion molecule-1

M Hagiyama, T Furuno, Y Hosokawa, T Iino… - The Journal of …, 2011 - journals.aai.org
Close apposition of nerve and mast cells is viewed as a functional unit of neuro-immune
mechanisms, and it is sustained by trans-homophilic binding of cell adhesion molecule-1 (…