Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …

In the fetus the major function of the ductus arteriosus is to divert flow away from the lungs
toward the placenta, therby avoiding unnecessary circulation through the lungs and reducing …

Osteosarcoma is the most frequent malignant primary bone tumor and a main cause of
cancer-related death in children and adolescents. Although long-term survival in localized …

When appropriately and correctly applied, the 0155 microsphere technique is relatively
simple and allows for definition of arteriovenous anastomoses as well as the measurement of …

Techniques are described for insertion of vinyl catheters into the umbilical and limb vessels
of the fetus of the sheep or the goat through small uterine incisions, with the ewes under …

With remarkable precision and reproducibility, cells orchestrate the cooperative action of
thousands of nanometre-sized molecular motors to carry out mechanical tasks at much larger …

Background Persistent pulmonary hypertension of the newborn causes systemic arterial
hypoxemia because of increased pulmonary vascular resistance and right-to-left shunting of …

Circulatory responses to hypoxemia and acidemia were studied in 10 fetal lambs in utero
with gestational ages of 122 to 142 days. Vinyl catheters were placed in fetal and maternal …

Aberrant activation of innate immune pathways is associated with a variety of diseases.
Progress in understanding the molecular mechanisms of innate immune pathways has led to the …

Inhibition of prostaglandin synthesis constricts the ductus arteriosus in fetal lambs in utero.
We administered the inhibitors, aspirin or indomethacin to 18 premature infants with patent …