Chelating agents in root canal treatment: mode of action and indications for their use

M Hülsmann, M Heckendorff… - International endodontic …, 2003 - Wiley Online Library
… Professor Dr M. Hülsmann, Department of Operative Dentistry, Preventive … 5 m sodium
hydroxide (9.25 mL) … The other ingredients are 9.25 mL 5 m sodium hydroxide and 100 mL …

An algorithm-based topographical biomaterials library to instruct cell fate

HV Unadkat, M Hulsman… - Proceedings of the …, 2011 - National Acad Sciences
It is increasingly recognized that material surface topography is able to evoke specific cellular
responses, endowing materials with instructive properties that were formerly reserved for …

[PDF][PDF] Complications during root canal irrigation–literature review and case reports.

M Hülsmann, W Hahn - International endodontic journal, 2000 - researchgate.net
… Hülsmann M, Denden JM (1997) Iatrogene Zwischenfälle bei der Wurzelkanalspülung –
Literaturübersicht und Falldarstellung. Endodontie 6, 191–205. Ingram TA (1990) Response of …

Dens invaginatus: aetiology, classification, prevalence, diagnosis, and treatment considerations

M Hülsmann - International endodontic journal, 1997 - Wiley Online Library
Dens invaginatus is a malformation of teeth probably resulting from an infolding of the dental
papilla during tooth development. Affected teeth show a deep infolding of enamel and …

Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis

H Holstege, W Pfeiffer, D Sie, M Hulsman… - Genome …, 2014 - genome.cshlp.org
The somatic mutation burden in healthy white blood cells (WBCs) is not well known. Based
on deep whole-genome sequencing, we estimate that approximately 450 somatic mutations …

[HTML][HTML] Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: a clinical interpretation strategy

H Holstege, SJ Van Der Lee, M Hulsman… - European Journal of …, 2017 - nature.com
Accumulating evidence suggests that genetic variants in the SORL1 gene are associated with
Alzheimer disease (AD), but a strategy to identify which variants are pathogenic is lacking. …

[HTML][HTML] A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the …

…, A Orellana, F Then Bergh, X Wang, M Hulsman… - Acta …, 2019 - Springer
The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously
associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in immune system …

Molecular mechanisms of biomaterial-driven osteogenic differentiation in human mesenchymal stromal cells

AMC Barradas, V Monticone, M Hulsman… - Integrative …, 2013 - academic.oup.com
Calcium phosphate (CaP) based ceramics are used as bone graft substitutes in the treatment
of bone defects. The physico-chemical properties of these materials determine their …

[HTML][HTML] Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease

H Holstege, M Hulsman, C Charbonnier… - Nature …, 2022 - nature.com
Alzheimer’s disease (AD), the leading cause of dementia, has an estimated heritability of
approximately 70% 1 . The genetic component of AD has been mainly assessed using genome-…

Mechanical preparation of root canals: shaping goals, techniques and means

M Hülsmann, OA Peters, PMH Dummer - Endodontic topics, 2005 - Wiley Online Library
Preparation of root canal systems includes both enlargement and shaping of the complex
endodontic space together with its disinfection. A variety of instruments and techniques have …