The increased availability of large-scale open-access resources on bioactivities of small
molecules has a significant impact on pharmacology facilitated mainly by computational …

Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor
malignancy and suppresses anti-tumor immunity. The context specificity of AHR target genes …

Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for
which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 …

To understand the structure and function of large molecular machines, accurate knowledge
of their stoichiometry is essential. In this study, we developed an integrated targeted …

In chronic lymphocytic leukemia (CLL), monocytes and macrophages are skewed toward
protumorigenic phenotypes, including the release of tumor-supportive cytokines and the …

Combinatorial therapy is a promising strategy for combating complex disorders due to
improved efficacy and reduced side effects. However, screening new drug combinations …

Aging is associated with the decline of protein, cell, and organ function. Here, we use an
integrated approach to characterize gene expression, bulk translation, and cell biology in the …

T cell exhaustion limits anti-tumor immunity and responses to immunotherapy. Here, we
explored the microenvironmental signals regulating T cell exhaustion using a model of chronic …

Drug perturbations of human cells lead to complex responses upon target binding. One of
the known mechanisms is a (positive or negative) feedback loop that adjusts the expression …

… We thank M. Brand for advice about FGF tagging, the EMBL Advanced Light Microscopy
Facility, in particular Y. Belyaev, for imaging assistance, the European Molecular Biology …