User profiles for M. J. Lemieux
 | M. Joanne LemieuxProfessor, University of Alberta Verified email at ualberta.ca Cited by 4920 |
Structure and Mechanism of the Glycerol-3-Phosphate Transporter from Escherichia coli
Y Huang, MJ Lemieux, J Song, M Auer, DN Wang - Science, 2003 - science.org
The major facilitator superfamily represents the largest group of secondary membrane
transporters in the cell. Here we report the 3.3 angstrom resolution structure of a member of this …
transporters in the cell. Here we report the 3.3 angstrom resolution structure of a member of this …
[HTML][HTML] Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
…, HS Young, DL Tyrrell, JC Vederas, MJ Lemieux - Nature …, 2020 - nature.com
The main protease, M pro (or 3CL pro ) in SARS-CoV-2 is a viable drug target because of its
essential role in the cleavage of the virus polypeptide. Feline infectious peritonitis, a fatal …
essential role in the cleavage of the virus polypeptide. Feline infectious peritonitis, a fatal …
[HTML][HTML] Comprehensive in vitro characterization of PD-L1 small molecule inhibitors
Blockade of the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1)
interaction has emerged as a powerful strategy in cancer immunotherapy. Recently, there …
interaction has emerged as a powerful strategy in cancer immunotherapy. Recently, there …
The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis
MJ Lemieux, SJ Fischer, MM Cherney… - Proceedings of the …, 2007 - National Acad Sciences
Rhomboid peptidases are members of a family of regulated intramembrane peptidases that
cleave the transmembrane segments of integral membrane proteins. Rhomboid peptidases …
cleave the transmembrane segments of integral membrane proteins. Rhomboid peptidases …
[HTML][HTML] A genetically encoded fluorescent biosensor for extracellular l-lactate
l-Lactate, traditionally considered a metabolic waste product, is increasingly recognized as
an important intercellular energy currency in mammals. To enable investigations of the …
an important intercellular energy currency in mammals. To enable investigations of the …
Membrane protein structure, function, and dynamics: a perspective from experiments and theory
Membrane proteins mediate processes that are fundamental for the flourishing of biological
cells. Membrane-embedded transporters move ions and larger solutes across membranes; …
cells. Membrane-embedded transporters move ions and larger solutes across membranes; …
Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies
…, HS Young, JA Nieman, DL Tyrrell, MJ Lemieux… - European journal of …, 2021 - Elsevier
Replication of SARS-CoV-2, the coronavirus causing COVID-19, requires a main protease (M
pro ) to cleave viral proteins. Consequently, M pro is a target for antiviral agents. We and …
pro ) to cleave viral proteins. Consequently, M pro is a target for antiviral agents. We and …
[HTML][HTML] Acyl-CoA: diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control
Acyl-CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) catalyzes the last reaction in
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly in …
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly in …
Peptidomimetic α-acyloxymethylketone warheads with six-membered lactam P1 glutamine mimic: SARS-CoV-2 3CL protease inhibition, coronavirus antiviral activity …
…, JC Vederas, DL Tyrrell, MJ Lemieux… - Journal of Medicinal …, 2021 - ACS Publications
Recurring coronavirus outbreaks, such as the current COVID-19 pandemic, establish a
necessity to develop direct-acting antivirals that can be readily administered and are active …
necessity to develop direct-acting antivirals that can be readily administered and are active …
Crystallographic structure of human β-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis
Lysosomal β-hexosaminidase A (Hex A) is essential for the degradation of G M2 gangliosides
in the central and peripheral nervous system. Accumulation of G M2 leads to severely …
in the central and peripheral nervous system. Accumulation of G M2 leads to severely …