Best disease (BD) is an inherited degenerative disease of the human macula that results in
progressive and irreversible central vision loss. It is caused by mutations in the retinal …

Numerous protocols have been described for producing neural retina from human pluripotent
stem cells (hPSCs), many of which are based on the culture of 3D organoids. Although …

Purpose.: We sought to determine if human induced pluripotent stem cells (iPSCs) derived
from blood could produce optic vesicle–like structures (OVs) with the capacity to stratify and …

… M. Joseph Phillips … Toivonen S Ojala M Hyysalo A Comparative analysis of targeted
differentiation of human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells …

Human induced pluripotent stem cells (hiPSCs) have been shown to differentiate along the
retinal lineage in a manner that mimics normal mammalian development. Under certain …

The Pde6brd10 (rd10) mouse has a moderate rate of photoreceptor degeneration and
serves as a valuable model for human autosomal recessive retinitis pigmentosa (RP). We …

Retinal ganglion cells (RGCs) are the projection neurons of the retina and transmit visual
information to postsynaptic targets in the brain. While this function is shared among nearly all …

Photoreceptor loss is a leading cause of blindness, but mechanisms underlying photoreceptor
degeneration are not well understood. Treatment strategies would benefit from improved …

Regenerative therapies aimed at replacing photoreceptors are a promising approach for the
treatment of otherwise incurable causes of blindness. However, such therapies still face …

Human pluripotent stem cells have made a remarkable impact on science, technology and
medicine by providing a potentially unlimited source of human cells for basic research and …