The intestinal epithelium represents a dual model system of differentiation that includes
processes that occur during ontogenesis and events that can be observed throughout the …

The intestinal epithelium is a particularly interesting tissue as (1) it is in a constant cell renewal
from a stem cell pool located in the crypts which form, with the underlying fibroblasts, a …

Intestinal morphogenesis and differentiation are dependent on heterotypic cell interactions
between embryonic epithelial cells (endoderm) and stromal cells (mesenchyme). …

… Similar observations have been made in the pancreas (M.Jenny and G.Gradwohl,
unpublished results). … Tissues were fixed for 10–20 min at room temperature in 0.2 …

The diverse functions of thyroid hormones are thought to be mediated by two nuclear receptors,
T3Rα1 and T3Rβ, encoded by the genes T3Rα and T3Rβ respectively. The T3Rα gene …

… Panels M and N are Pdx1 immunochemistry on adjacent sections of panels I and J. (O, P)
Hex1 is expressed in … We thank M. Messmer and V. Hauer for excellent technical assistance, V. …

Background: During development, the homeobox gene Cdx2 exerts a homeotic function,
providing the positional information necessary for correct specification of the midgut endoderm. …

To explore the role of homeobox genes in the intestine, the human colon adenocarcinoma
cell line Caco2-TC7 has been stably transfected with plasmids synthesizing Cdx1 and Cdx2 …

This study was designed to investigate the efficacy of photodynamic therapy (PDT) in treating
colonic cancer in a preclinical study. Photofrin®, a porphyrin mixture, and pheophorbide a (…

… epithelial cells constitutive signaling by oncogenic Ras also affects the production of NO,
another proinflammatory mediator, we induced Ras signaling in IEC-iK-Ras cells with 5 mm …