White adipose (fat) tissues regulate metabolism, reproduction, and life span. Adipocytes
form throughout life, with the most marked expansion of the lineage occurring during the …

… anti-CXCR4 (Pharmingen), and mouse anti-M-cadherin (clone 5; Pharmingen) antibodies.
For secondary staining in the case of M-cadherin, we used APC-conjugated goat anti-mouse …

The extent to which primitive embryonic blood progenitors contribute to definitive lymphoid-myeloid
hematopoiesis in the adult remains uncertain. In an effort to characterize factors that …

Immune-deficient Rag2 −/− mice were used as nuclear donors for transfer into enucleated
oocytes, and the resulting blastocysts were cultured to isolate an isogenic embryonic stem cell …

… mechanical homogenization of placentas in lysis buffer (0.32M sucrose, 5 mM CaCl 2 , 5 mM
… We thank M. Iacovino for creating the A2lox-cre ES cell line. We would also like to thank T. …

Each unit of the D4Z4 macrosatellite repeat contains a retrotransposed gene encoding the
DUX4 double-homeobox transcription factor. Facioscapulohumeral dystrophy (FSHD) is …

A major obstacle in the application of cell-based therapies for the treatment of neuromuscular
disorders is obtaining the appropriate number of stem/progenitor cells to produce effective …

Embryonic stem (ES) cells have tremendous potential as a cell source for cell‐based therapies.
Realization of that potential will depend on our ability to understand and manipulate the …

During embryonic development, multipotent cardiovascular progenitor cells are specified
from early mesoderm. Using mouse ESCs in which gene expression can be temporally …

Little progress has been made toward the use of embryonic stem (ES) cells to study and
isolate skeletal muscle progenitors. This is due to the paucity of paraxial mesoderm formation …