G-protein-coupled receptors signalling at the cell nucleus: an emerging paradigm

…, M Bossolasco, M Leduc, M Grandbois… - Canadian journal of …, 2006 - cdnsciencepub.com
G-protein-coupled receptors (GPCRs) comprise a wide family of monomeric heptahelical
glycoproteins that recognize a broad array of extracellular mediators including cationic amines, …

Cold and trapped metastable noble gases

W Vassen, C Cohen-Tannoudji, M Leduc, D Boiron… - Reviews of Modern …, 2012 - APS
… In this case also m ž 0 and m ž Ā1 atoms as well as mixtures of different m states can be
trapped. As only a spin-polarized gas of either m ž þ1 or m ž Ā1 atoms is stable against Penning …

[HTML][HTML] Clinical whole-exome sequencing for the diagnosis of mendelian disorders

…, R Person, MR Bekheirnia, MS Leduc… - … England Journal of …, 2013 - Mass Medical Soc
Background Whole-exome sequencing is a diagnostic approach for the identification of
molecular defects in patients with suspected genetic disorders. Methods We developed technical…

Molecular findings among patients referred for clinical whole-exome sequencing

…, N Veeraraghavan, A Hawes, T Chiang, M Leduc… - Jama, 2014 - jamanetwork.com
Importance Clinical whole-exome sequencing is increasingly used for diagnostic evaluation
of patients with suspected genetic disorders. Objective To perform clinical whole-exome …

[HTML][HTML] An overview of duplicated gene detection methods: Why the duplication mechanism has to be accounted for in their choice

T Lallemand, M Leduc, C Landès, C Rizzon, E Lerat - Genes, 2020 - mdpi.com
Gene duplication is an important evolutionary mechanism allowing to provide new genetic
material and thus opportunities to acquire new gene functions for an organism, with major …

Self-condensing vinyl polymerization: an approach to dendritic materials

JMJ Frechet, M Henmi, I Gitsov, S Aoshima, MR Leduc… - Science, 1995 - science.org
Self-condensing vinyl polymerization was used to produce dendritic polymers with both
highly branched structures and numerous reactive groups. A vinyl monomer will undergo self-…

Bose-Einstein condensation of metastable helium

…, F Perales, E Rasel, CS Unnikrishnan, M Leduc… - Physical Review Letters, 2001 - APS
We have observed a Bose-Einstein condensate in a dilute gas of 4 He in the 2 S 1 3 metastable
state. We find a critical temperature of (4.7±0.5) μ K and a typical number of atoms at the …

Use of exome sequencing for infants in intensive care units: ascertainment of severe single-gene disorders and effect on medical management

…, DM Muzny, MJ Miller, X Wang, MS Leduc… - JAMA …, 2017 - jamanetwork.com
Importance While congenital malformations and genetic diseases are a leading cause of
early infant death, to our knowledge, the contribution of single-gene disorders in this group is …

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis

…, DR Varma, S Tremblay, M Leduc… - Nature medicine, 2008 - nature.com
… We calculated the ratios of the areas of the peaks at m/z 297 and m/z 301 and converted
them to weight of endogenous succinate per cell protein content or total sample weight. Details …

[HTML][HTML] Potential role of microglia in retinal blood vessel formation

…, F Sennlaub, E Levavasseur, M Leduc… - … & visual science, 2006 - arvojournals.org
purpose. The role of microglia, present in the retina early in development before vascularization,
remains ill defined. The authors investigated whether microglia are implicated in retinal …