Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified
more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data …

Prostate cancer is a highly heritable disease with large disparities in incidence rates across
ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer …

Genome-wide association studies (GWAS) have identified 76 variants associated with
prostate cancer risk predominantly in populations of European ancestry. To identify additional …

Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed
countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-…

Prostate cancer has a strong familial component but uncovering the molecular basis for
inherited susceptibility for this disease has been challenging. Recently, a rare, recurrent …

Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic
basis, but this has not been investigated systematically by genome-wide association (GWA) …

Objectives To develop and validate a genetic tool to predict age of onset of aggressive prostate
cancer (PCa) and to guide decisions of who to screen and at what age. Design Analysis …

Molecular modifications of the androgen receptor (AR) can cause resistance to androgen
deprivation therapy (ADT) in prostate cancer patients. Since lack of representative tumor …

Genome-wide association studies (GWAS) have identified multiple common genetic variants
associated with an increased risk of prostate cancer (PrCa), but these explain less than one-…

The transferability and clinical value of genetic risk scores (GRSs) across populations remain
limited due to an imbalance in genetic studies across ancestrally diverse populations. Here …