Introduction Several lines of evidence point to a key role for dynamic epigenetic changes
during brain development, maturation, and learning. DNA methylation (mC) is a stable covalent …

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …

Abuse of the dissociative anesthetic ketamine can lead to a syndrome indistinguishable
from schizophrenia. In animals, repetitive exposure to this N-methyl-d-aspartate–receptor …

Identification of the cis-regulatory elements controlling cell-type specific gene expression
patterns is essential for understanding the origin of cellular diversity. Conventional assays to …

The mammalian brain contains diverse neuronal types, yet we lack single-cell epigenomic
assays that are able to identify and characterize them. DNA methylation is a stable epigenetic …

Excessive zinc influx may contribute to neuronal death after certain insults, including transient
global ischemia. In light of evidence that levels of intracellular free Zn 2+ associated with …

Several lines of evidence suggest that a hypoglutamatergic condition may induce a phenotypic
loss of cortical parvalbumin (PV)-positive GABAergic interneurons, such as that observed …

Genome-wide profiling of histone modifications can reveal not only the location and activity
state of regulatory elements, but also the regulatory mechanisms involved in cell-type-…

Simultaneous profiling of transcriptome and chromatin accessibility within single cells is a
powerful approach to dissect gene regulatory programs in complex tissues. However, current …

Mammalian brain cells show remarkable diversity in gene expression, anatomy and function,
yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly …