The fatty acid chain elongation system of mammalian endoplasmic reticulum

DL Cinti, L Cook, MN Nagi, SK Suneja - Progress in lipid research, 1992 - Elsevier
B. Coenzyme A derivatives as substrates for microsomal FACES IV. Rv. Ac'nolcs CATALYZFD
BY THE HEPATIC FACES A. The first elongation step: condensation reaction B. The …

Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT‐diaphorase in different tissues of mice: a possible mechanism of action

MA Mansour, MN Nagi, AS El‐Khatib… - Cell biochemistry and …, 2002 - Wiley Online Library
The present investigation focused, firstly, on the effects of oral administration of thymoquinone
(TQ) on antioxidant enzyme activities, lipid peroxidation and DT‐diaphorase activity in …

Protective effect of thymoquinone against doxorubicin–induced cardiotoxicity in rats: A possible mechanism of protection

MN Nagi, MA Mansour - Pharmacological research, 2000 - Elsevier
… The reaction was initiated by adding 5 M PMS and the production of formazan was followed
at 560 nm at 20C for 5 min. Data were plotted as a percentage of the remaining absorbance …

Thymoquinone protects against carbon tetrachloride hetatotoxicity in mice via an antioxidant mechanism

MN Nagi, K Alam, OA Badary, OA Al‐Shabanah… - IUBMB …, 1999 - Wiley Online Library
Thymoquinone (TQ) is the major active component of the volatile oil of Nigella sativa seeds.
The effects of TQ on carbon tetrachloride (CC14)‐induced hepatotoxicity was investigated in …

Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity

OA Badary, MN Nagi, OA Al-Shabanah… - Canadian journal of …, 1997 - cdnsciencepub.com
The effects of thymoquinone (TQ) on cisplatin-induced nephrotoxicity in mice and rats were
studied. Oral administration of TQ (50 mg/L in drinking water) for 5 days before and 5 days …

Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus

AA Al-Majed, FA Al-Omar, MN Nagi - European journal of pharmacology, 2006 - Elsevier
Increasing evidence demonstrates that oxidative stress plays an important role in brain
injury in experimental models of brain ischemia. Thymoquinone, the main constituents of the …

Inhibition of benzo (a) pyrene-induced forestomach carcinogenesis in mice by thymoquinone

OA Badary, OA Ai-shabanah, MN Nagi… - European Journal of …, 1999 - journals.lww.com
The modulating effect of thymoquinone (TQ) on benzo (a) pyrene (BP)-induced forestomach
tumours was investigated in female Swiss albino mice, receiving oral administration of BP at …

Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4 (3H)-quinazolinone analogs

ST Al-Rashood, IA Aboldahab, MN Nagi… - Bioorganic & medicinal …, 2006 - Elsevier
In order to produce potent new leads for anticancer drugs, a new series of quinazoline
analogs was designed to resemble methotrexate (MTX, 1) structure features and fitted with …

Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling

…, OA Al-Shabanah, MM Hafez, MN Nagi - … medicine and cellular …, 2010 - hindawi.com
Hepatocellular carcinoma accounts for about 80–90% of all liver cancer and is the fourth most
common cause of cancer mortality. Although there are many strategies for the treatment of …

Acute and subchronic toxicity of thymoquinone in mice

…, MN Nagi, AM Al‐Bekairi, M Elmazar - Drug Development …, 1998 - Wiley Online Library
Nagi, Abdullah M. Al-Bekairi, and Mohamed MA Elmazar … Al-Shabanah OA, Badary OA,
Nagi MN, Al-Gharably NM, Al-Rikabi AM, Al-Bekairi AM (1998): Thymoquinone protects …