Following axon pathfinding, growth cones transition from stochastic filopodial exploration to
the formation of a limited number of synapses. How the interplay of filopodia and synapse …

For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most
studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula …

Deciphering how neuronal diversity is established and maintained requires a detailed
knowledge of neuronal gene expression throughout development. In contrast to mammalian …

The brain consists of thousands of neuronal types that are generated by stem cells producing
different neuronal types as they age. In Drosophila, this temporal patterning is driven by …

10.7554/eLife.01064.001 The small GTPase Rab7 is a key regulator of endosomal maturation
in eukaryotic cells. Mutations in rab7 are thought to cause the dominant neuropathy …

10.7554/eLife.10721.001 Filopodial dynamics are thought to control growth cone guidance,
but the types and roles of growth cone dynamics underlying neural circuit assembly in a …

Neurons are highly polarized cells that require continuous turnover of membrane proteins at
axon terminals to develop, function, and survive. Yet, it is still unclear whether membrane …

The large diversity of cell types in nervous systems presents a challenge in identifying the
genetic mechanisms that encode it. Here, we report that nearly 200 distinct neurons in the …

10.7554/eLife.01699.001 Axonal branching allows a neuron to connect to several targets,
increasing neuronal circuit complexity. While axonal branching is well described, the …

The brain consists of thousands of different neuronal types that are generated through multiple
divisions of neuronal stem cells. These stem cells have the capacity to generate different …