Multiple aspects of neuronal physiology crucially depend on two cellular pathways,
autophagy and endocytosis. During endocytosis, extracellular components either unbound or …

Overexpression of Ras G12V in primary cells induces a permanent growth arrest called
oncogene-induced senescence (OIS) that serves as a fail-safe mechanism against malignant …

The efficiency with which small interfering RNAs (siRNAs) down-regulate specific gene
expression in living cells is variable and a number of sequence-governed, biochemical …

Autophagy provides nutrients during starvation and eliminates detrimental cellular
components. However, accumulating evidence indicates that autophagy is not merely a …

p16 is a key regulator of cellular senescence, yet the drivers of this stable state of proliferative
arrest are not well understood. Here, we identify 22 senescence-associated microRNAs (…

Neurons maintain axonal homeostasis via employing a unique organization of the
microtubule (MT) cytoskeleton, which supports axonal morphology and provides tracks for …

The phosphorothioate(PS)-stimulated cellular uptake of naked short interfering RNA (siRNA)
into mammalian cells indicates a promising new mechanistic strategy because it makes …

The cellular uptake of oligomeric nucleic acid-based tools and drugs including small-interfering
RNA (siRNA) represents a major technical hurdle for the biologic effectiveness and …

… The MS1 survey scan was acquired from 300 to 1,750 m/z at a resolution of 70,000. The
top 10 most abundant peptides were isolated within a 1.8 Th window and subjected to HCD …

… An additional DNA denaturation step with 4 M HCl for 10 min was performed following
permeabilisation, and a conjugated mouseαBrdU-AlexaFlur-488 antibody (1:100, B35130 …