User profiles for M. Pellikka

Matti Pellikka

Grundium Ltd
Verified email at grundium.com
Cited by 185

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

J Yrjänheikki, R Keinänen, M Pellikka… - Proceedings of the …, 1998 - National Acad Sciences
Ischemic stroke is the most common life-threatening neurological disease and has limited
therapeutic options. One component of ischemic neuronal death is inflammation. Here we …

Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis

M Pellikka, G Tanentzapf, M Pinto, C Smith… - Nature, 2002 - nature.com
The apical transmembrane protein Crumbs is a central regulator of epithelial apical–basal
polarity in Drosophila. Loss-of-function mutations in the human homologue of Crumbs, CRB1 (…

Monomeric α-catenin links cadherin to the actin cytoskeleton

R Desai, R Sarpal, N Ishiyama, M Pellikka, M Ikura… - Nature cell …, 2013 - nature.com
The linkage of adherens junctions to the actin cytoskeleton is essential for cell adhesion.
The contribution of the cadherin–catenin complex to the interaction between actin and the …

[PDF][PDF] The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size

P Laprise, S Beronja, NF Silva-Gagliardi, M Pellikka… - Developmental cell, 2006 - cell.com
The Crumbs (Crb) complex is a key regulator of epithelial cell architecture where it promotes
apical membrane formation. Here, we show that binding of the FERM protein Yurt to the …

Normal range criteria for indoor air bacteria and fungal spores in a subarctic climate

T Reponen, A Nevalainen, M Jantunen, M Pellikka… - Indoor …, 1992 - Wiley Online Library
Indoor air bacteria and fingal spore levels were studied in 71 non‐complaint homes. lk data
were analyzed according to the season and the higher limit of the range within which 95% of …

[PDF][PDF] The agrin/perlecan-related protein eyes shut is essential for epithelial lumen formation in the Drosophila retina

N Husain, M Pellikka, H Hong, T Klimentova… - Developmental cell, 2006 - cell.com
The formation of epithelial lumina is a fundamental process in animal development. Each
ommatidium of the Drosophila retina forms an epithelial lumen, the interrhabdomeral space, …

Mutational analysis supports a core role for Drosophila α-Catenin in adherens junction function

R Sarpal, M Pellikka, RR Patel, FYW Hui… - Journal of cell …, 2012 - journals.biologists.com
α-catenin associates the cadherin–catenin complex with the actin cytoskeleton. α-catenin
binds to β-catenin, which links it to the cadherin cytoplasmic tail, and F-actin, but also to a …

Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells

S Beronja, P Laprise, O Papoulas, M Pellikka… - The Journal of cell …, 2005 - rupress.org
Polarized exocytosis plays a major role in development and cell differentiation but the
mechanisms that target exocytosis to specific membrane domains in animal cells are still poorly …

Homology and cohomology computation in finite element modeling

M Pellikka, S Suuriniemi, L Kettunen… - SIAM Journal on Scientific …, 2013 - SIAM
… Results of the homology and cohomology solver are the bases for the relative homology
spaces Hk(M,S) and the relative cohomology spaces Hk (M,S) of the domain M and its …

Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly

JT Silver, F Wirtz-Peitz, S Simões, M Pellikka… - Journal of Cell …, 2019 - rupress.org
… RNAi phenotype, and lgl 4 (M/Z) fully suppressed the cyst 1 (M/Z) phenotype, with double
mutants showing phenotypes indistinguishable from scrib RNAi or lgl 4 (M/Z) alone (Fig. 1, I, …