Structures of macromolecular complexes are necessary for a mechanistic description of
biochemical and cellular processes. They can be solved by experimental methods, such as X-…

Only a tiny fraction of the many hundreds of known protein complexes are also of known
three-dimensional structure. The experimental difficulties surrounding structure determination of …

The gut microbiome is important for human health, yet modulation requires more insight into
inter-individual variation. Here, we explored latent structures of the human gut microbiome …

Motivation Analysis toolkits for shotgun metagenomic data achieve strain-level characterization
of complex microbial communities by capturing intra-species gene content variation. Yet, …

Background Smoking has a negative impact on Crohn's disease (CD), but the mechanisms
underlying this association are unclear. We compared the gut microbiota composition of …

Bacterial ADP-ribosyltransferases (ADPRTs) have been described as toxins involved in
pathogenesis through the modification of host proteins. Here, we report that ADPRTs are not …

Background Immunoglobulin G4-related disease (IgG4-RD) and systemic sclerosis (SSc) are
rare autoimmune diseases characterized by the presence of CD4+ cytotoxic T cells in the …

Background The endoplasmic reticulum (ER) is a membranous organelle that maintains
proteostasis and cellular homeostasis, controlling the fine balance between health and disease. …

Elucidating how resident enteric bacteria interact with their hosts to promote health or
inflammation is of central importance to diarrheal and inflammatory bowel diseases across species…

We describe the present state and future evolution of the Virgo gravitational wave detector,
realized by the Virgo Collaboration at the European Gravitational Observatory, in Cascina …