Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases,
such as osteoporosis, diabetes and obesity. Here we report the structure of a full-length …

The class B glucagon-like peptide-1 (GLP-1) G protein-coupled receptor is a major target for
the treatment of type 2 diabetes and obesity 1 . Endogenous and mimetic GLP-1 peptides …

With the advent of direct electron detectors, the perspectives of cryo-electron microscopy (cryo-EM)
have changed in a profound way. These cameras are superior to previous detectors …

Calcitonin gene-related peptide (CGRP) is a widely expressed neuropeptide that has a major
role in sensory neurotransmission. The CGRP receptor is a heterodimer of the calcitonin …

Mycobacterium tuberculosis has evolved a number of strategies to survive within the hostile
environment of host phagocytes. Reactive nitrogen and oxygen intermediates (RNI and ROI) …

Since the early 2010s, cryo-electron microscopy (cryo-EM) has evolved to a mainstream
structural biology method in what has been dubbed the “resolution revolution”. Pharma …

… buffer-exchanged into 20 mm Tris-HCl, pH 8.0, 0.3 m NaCl, 20 mm imidazole by extensive
dialysis or … 40 mm imidazole and the His-tagged MPEG1 eluted with buffer containing 500 mm …

Cryo-EM of large, macromolecular assemblies has seen a significant increase in the numbers
of high-resolution structures since the arrival of direct electron detectors. However, sub-…

Complement component 9 (C9) functions as the pore-forming component of the Membrane
Attack Complex (MAC). During MAC assembly, multiple copies of C9 are sequentially …

The assembly and regulation of viral capsid proteins into highly ordered macromolecular
complexes is essential for viral replication. Here, we utilize crystal structures of the capsid …