Neospora caninum is regarded as one of the most important infectious causes of abortions
in cattle worldwide, yet the global economic impact of the infection has not been established. …

Acid sphingomyelinase (ASM) is an important lipid-metabolizing enzyme cleaving
sphingomyelin to ceramide, mainly within lysosomes. Acid ceramidase (AC) further degrades …

Bovine viral diarrhoea virus (BVDV) is the most prevalent infectious disease of cattle. It causes
financial losses from a variety of clinical manifestations and is the subject of a number of …

Major depression is a highly prevalent severe mood disorder that is treated with antidepressants.
The molecular targets of antidepressants require definition. We investigated the role of …

The gene Prph2 encodes a photoreceptor-specific membrane glycoprotein 1, peripherin-2 (also
known as peripherin/rds), which is inserted into the rims of photoreceptor outer segment …

Major depression and anxiety disorders have high prevalence rates and are frequently
comorbid. The neurobiological bases for these disorders are not fully understood, and available …

Gene transfer to photoreceptor cells may provide a means for arresting the retinal
degeneration that is characteristic of many inherited causes of blindness, including retinitis …

The goal of this study was to explore associations between maternal personality traits, child
temperament characteristics, and parenting styles linked to the display and regulation of …

Some organic weak bases induce a detachment from inner lysosomal membranes and
subsequent inactivation of acid sphingomyelinase (ASM) and thus work as functional ASM …

We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional
inhibition of acid sphingomyelinase (ASM). These entities named FIASMAs (Functional …