Both complex disorders and monogenetic diseases are often modulated in their phenotype
by further genetic, epigenetic or extrinsic factors. This gives rise to extensive phenotypic …

Proximal spinal muscular atrophy (SMA) is a common autosomal recessively inherited
neuromuscular disorder determined by functional impairment of α-motor neurons within the spinal …

<p id="p001">Plastin 3 (PLS3), a protein involved in the formation of filamentous actin (F-actin)
bundles, appears to be important in human bone health, on the basis of pathogenic …

The autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA) results
from low levels of survival motor neuron (SMN) protein; however, it is unclear how reduced …

… TVA was stained with anti-NF-M (Neurofilament M, NEFM, used as neuronal axon and
dendritic marker [Hybridoma-Bank]) and with secondary goat-anti mouse AlexaFluor488 and …

… The recombinant GST-PLS3 protein was circulated over the m columns for 20 min. Afterward,
m columns were washed, and the bound protein fraction was eluted with 95 C Laemmli …

Immune responses are arising as a common feature of several neurodegenerative diseases,
such as Parkinson’s Disease (PD), Alzheimer’s Disease (AD), and Amyotrophic Lateral …

The recent FDA-approval for amyloid lowering therapies reflects an unwavering commitment
from the Alzheimer’s disease (AD) research community to identify treatments for this …

F-actin bundling plastin 3 (PLS3) is a fully protective modifier of the neuromuscular disease
spinal muscular atrophy (SMA), the most common genetic cause of infant death. The …

… 50 nm siRNA and 50 nm LNA inhibitors are transfected to cortical neurons. Western blots
were repeated twice with two different biological samples. Data represent mean ± SEM. …