More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

Recent evidence suggests that calorie restriction and specifically reduced glucose metabolism
induces mitochondrial metabolism to extend life span in various model organisms, …

Various nutritional, behavioral, and pharmacological interventions have been previously
shown to extend life span in diverse model organisms, including Saccharomyces cerevisiae, …

Exercise promotes longevity and ameliorates type 2 diabetes mellitus and insulin resistance.
However, exercise also increases mitochondrial formation of presumably harmful reactive …

A subclinical inflammatory reaction has been shown to precede the onset of type 2 (non-insulin-dependent)
diabetes. We therefore examined prospectively the effects of the central …

Adiponectin is an adipocyte-derived peptide, which has antiinflammatory and insulin-sensitising
properties. We designed a nested case-control study to assess whether baseline …

… 0.5 M stock solution for DOG and to final concentrations of 5 and 50 mM from a 1 M aqueous
stock for D-glucose. NAC was used at a final concentration of 5 mM from a 0.5 M aqueous …

Background There is increasing evidence of genetic factors leading to obesity, but the exact
genes involved have not been defined. Peroxisome-proliferator–activated receptor γ2 (…

Activation of peroxisome proliferator-activated receptor γ (PPARγ) by thiazolidinediones (TZDs)
improves insulin resistance by increasing insulin-stimulated glucose disposal in skeletal …

Objective: The marked increase in the prevalence of obesity in the United States has recently
been attributed to the increased fructose consumption. To determine if and how fructose …