Angiotensin II (AngII), the major effector peptide of renin–angiotensin system (RAS), is now
recognized as a growth factor that regulates cell growth and fibrosis, besides being a …

Background The migration of monocytes into the vessel wall is a critical event leading to the
development of atherosclerosis. Monocyte chemoattractant protein-1 (MCP-1) is the main …

… In addition, in nephritic rats, ACE inhibition diminished renal CTGF expression correlated
with diminution of TGFβ and fibrosis (M. Ruiz-Ortega and J. Egido, unpublished data, 2001), …

Transforming growth factor-β (TGF-β) participates in the pathogenesis of multiple cardiovascular
diseases, including hypertension, restenosis, atherosclerosis, cardiac hypertrophy and …

The NF-κB family of transcription factors regulates the induction and resolution of inflammation.
Two main pathways, classical and alternative, control the nuclear translocation of NF-κB. …

Many experimental data have suggested that the renin-angiotensin system participates in
immune and inflammatory responses. Angiotensin II is involved in several steps of the …

… Author links open overlay panel Marta Ruiz-Ortega , Mónica Ruperez , Oscar Lorenzo,
Vanesa Esteban , Julia Blanco , Sergio Mezzano , Jesus Egido … Ruiz-Ortega, et al. …

Background. Nuclear factor-κB (NF-κB) regulates genes involved in renal disease progression,
such as the chemokines monocyte chemoattractant protein-1 (MCP-1) and RANTES. NF-…

… Marta Ruiz-Ortega … Ruiz-Ortega M, Lorenzo O, Ruperez M et al. Systemic infusion of
angiotensin II into normal rats activates nuclear factor κ-B and AP-1 in the kidney. Role of AT1 and …

Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well as …