Early myeloid lineage choice is not initiated by random PU. 1 to GATA1 protein ratios

PS Hoppe, M Schwarzfischer, D Loeffler… - Nature, 2016 - nature.com
… This work was supported by an EMBO long-term fellowship to M.Et., the ‘EUCOMM: Tools
for Functional Annotation of the Mouse Genome’ (EUCOMMTOOLS) project (FP7-HEALTH-F4-…

[PDF][PDF] Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors

…, G Rogler, K Baebler, M Schwarzfischer… - Cell host & …, 2021 - cell.com
Despite overall success, T cell checkpoint inhibitors for cancer treatment are still only efficient
in a minority of patients. Recently, intestinal microbiota was found to critically modulate anti-…

[HTML][HTML] The intestinal barrier—shielding the body from nano-and microparticles in our diet

M Schwarzfischer, G Rogler - Metabolites, 2022 - mdpi.com
Nano- and microparticles are an implicit part of the human diet. They are unknowingly
ingested with our food that contains them as additives or pollutants. However, their impact on …

Software tools for single-cell tracking and quantification of cellular and molecular properties

O Hilsenbeck, M Schwarzfischer, S Skylaki… - Nature …, 2016 - nature.com
Schwarzfischer, M. et al. Efficient fluorescence image normalization for time lapse movies. …
TS planned and supervised the study and wrote the manuscript with OH, M.Sc. and SS All …

Prospective identification of hematopoietic lineage choice by deep learning

…, M Endele, M Kroiss, M Strasser, M Schwarzfischer… - Nature …, 2017 - nature.com
… Strasser and M. Schwarzfischer contributed to image processing and data analysis. PSH
developed and conducted all experiments and tracked cells with ME; TS developed and …

[HTML][HTML] An automatic method for robust and fast cell detection in bright field images from high-throughput microscopy

F Buggenthin, C Marr, M Schwarzfischer, PS Hoppe… - BMC …, 2013 - Springer
m m 2 ) over all fields of view at the given time point. After 12 hours (Figure 2A), all fields of
view were sparsely covered with cells (cell density 5.6±2.4 1/m m 2 … patch) per m m 2 covering …

Network plasticity of pluripotency transcription factors in embryonic stem cells

…, S Hastreiter, J Feigelman, M Schwarzfischer… - Nature cell …, 2015 - nature.com
Transcription factor (TF) networks are thought to regulate embryonic stem cell (ESC) pluripotency.
However, TF expression dynamics and regulatory mechanisms are poorly understood. …

fastER: a user-friendly tool for ultrafast and robust cell segmentation in large-scale microscopy

O Hilsenbeck, M Schwarzfischer, D Loeffler… - …, 2017 - academic.oup.com
… The complexity of our implementation is O ( n m ) , where n is the number of pixels and
m the number of possible greylevels in the image (see Supplementary Note S1.4 for runtime …

[HTML][HTML] The role of protein tyrosine phosphatases in inflammasome activation

MR Spalinger, M Schwarzfischer, M Scharl - International journal of …, 2020 - mdpi.com
Inflammasomes are multi-protein complexes that mediate the activation and secretion of the
inflammatory cytokines IL-1β and IL-18. More than half a decade ago, it has been shown …

Ingested nano-and microsized polystyrene particles surpass the intestinal barrier and accumulate in the body

M Schwarzfischer, A Niechcial, SS Lee, B Sinnet… - NanoImpact, 2022 - Elsevier
Plastic pollution is a major global challenge of our times, baring a potential threat for the
environment and the human health. The increasing abundance of nanoplastic (NP) and …