Several lines of evidence indicate that during transformation epithelial cancer cells can acquire
mesenchymal features via a process called epithelial‐to‐mesenchymal transition ( EMT )…

The permeability transition pore (PTP) is an inner mitochondrial membrane channel that has
been thoroughly characterized functionally, yet remains an elusive molecular entity. The …

Cancer is a complex and heterogeneous disease thought to be caused by multiple genetic
lesions. The recent finding that enzymes of the tricarboxylic acid (TCA) cycle are mutated in …

Mutations of the tricarboxylic acid cycle enzyme fumarate hydratase cause hereditary
leiomyomatosis and renal cell cancer 1 . Fumarate hydratase-deficient renal cancers are highly …

We report that the mitochondrial chaperone TRAP1, which is induced in most tumor types, is
required for neoplastic growth and confers transforming potential to noncancerous cells. …

Mutations in the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase (FH) are associated
with a highly malignant form of renal cancer. We combined analytical chemistry and …

We studied human cancer cell models in which we detected constitutive activation of ERK. A
fraction of active ERK was found to be located in mitochondria in RWPE-2 cells, obtained by …

Context: At least a third of the patients with pheochromocytoma (PCC) or paraganglioma (PGL)
harbor an underlying germline mutation in a known PCC/PGL gene. Mutations in genes (…

… Isolation width was set at 0.8 m/z and a fixed first mass of 100 m/z was used. Normalized
collision energy was set at 33%. Peptide match was set to off, and isotope exclusion was on. …

Cancer cells exhibit profound metabolic alterations, allowing them to fulfill the metabolic
needs that come with increased proliferation and additional facets of malignancy. Such a …