User profiles for M. Shen

Morgan Sheng

- Verified email at mit.edu - Cited by 80322

Michael M. Shen

- Verified email at columbia.edu - Cited by 24066

Mengyan Shen

- Verified email at uml.edu - Cited by 12064

Molecular genetics of prostate cancer: new prospects for old challenges

MM Shen, C Abate-Shen - Genes & development, 2010 - genesdev.cshlp.org
Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the androgen …

Remdesivir: a review of its discovery and development leading to emergency use authorization for treatment of COVID-19

…, KR Brimacombe, A Simeonov, M Shen… - ACS central …, 2020 - ACS Publications
The global pandemic of SARS-CoV-2, the causative viral pathogen of COVID-19, has driven
the biomedical community to action—to uncover and develop antiviral interventions. One …

Molecular genetics of prostate cancer

C Abate-Shen, MM Shen - Genes & development, 2000 - genesdev.cshlp.org
Prostate cancer afflicts one man in nine over the age of 65 and represents the most frequently
diagnosed cancer in American men (Coffey 1993). Early detection through serum testing …

Logistic-normal distributions: Some properties and uses

J Atchison, SM Shen - Biometrika, 1980 - academic.oup.com
The logistic transformation applied to a d-dimensional normal distribution produces a
distribution over the d-dimensional simplex which can sensibly be termed a logistic-normal …

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

…, YL Cheng, JQ Yang, SK Shen, J Li, YJ Sheng… - Nature …, 2009 - nature.com
We performed a genome-wide association study (GWAS) of systemic lupus erythematosus (SLE)
in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using …

Optically pumped lasing of ZnO at room temperature

…, YF Chen, Z Zhu, T Yao, S Koyama, MY Shen… - Applied physics …, 1997 - pubs.aip.org
We report the observation of optically pumped lasing in ZnO at room temperature. Thin films
of ZnO were grown by plasma-enhanced molecular beam epitaxy on (0001) sapphire …

Statistical potential for assessment and prediction of protein structures

M Shen, A Sali - Protein science, 2006 - Wiley Online Library
m,n (r) as p m,n (r;a). The key simplification in the calculation of the normalization function p
m,… ) for which the calculation of p m,n (r;a) is analytically tractable and then assume that this p …

IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex

…, G Gallagher, VV Baurin, A Lewis-Antes, M Shen… - Nature …, 2003 - nature.com
We report here the identification of a ligand-receptor system that, upon engagement, leads
to the establishment of an antiviral state. Three closely positioned genes on human …

Obesity-associated variants within FTO form long-range functional connections with IRX3

…, JH Lee, V Puviindran, D Tam, M Shen… - Nature, 2014 - nature.com
Genome-wide association studies (GWAS) have reproducibly associated variants within
introns of FTO with increased risk for obesity and type 2 diabetes (T2D) 1 , 2 , 3 . Although the …

Changing subunit composition of heteromeric NMDA receptors during development of rat cortex

M Sheng, J Cummings, LA Roldan, YN Jan, LY Jan - Nature, 1994 - nature.com
… Feger and M. Hattori for help with antibody preparation, and B, Zhao, CL. Huang and M.
Stryker for critical reading of the manuscript. This work was supported by the Silvio Conte Center …