Significance: Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique to
distinguish the unique molecular environment of fluorophores. FLIM measures the time a …

The move from reading to writing the human genome offers new opportunities to improve
human health. The United States National Institutes of Health (NIH) Somatic Cell Genome …

Metabolic imaging of the relative amounts of reduced NADH and FAD and the microenvironment
of these metabolic electron carriers can be used to noninvasively monitor changes in …

Background Stereotactic ablative body radiotherapy (SABR) is widely used to treat
inoperable stage 1 non-small-cell lung cancer (NSCLC), despite the absence of prospective …

Multiphoton fluorescence lifetime imaging microscopy (FLIM) is a noninvasive, cellular
resolution, 3-D functional imaging technique. We investigate the potential for in vivo precancer …

Background. —Food-borne transmission is now recognized as a major cause of human
listeriosis. Objective. —To assess the impact of prevention efforts, listeriosis rates before …

The unique metabolic demands of cancer cells underscore potentially fruitful opportunities
for drug discovery in the era of precision medicine. However, therapeutic targeting of cancer …

… τ m , and FAD τ m images of … m , and FAD τ m images of organoids derived from primary,
human breast tumors. Redox ratio (NADH/FAD; first row), NADH τ m (second row), and FAD τ m …

The retinal pigment epithelium (RPE) is essential to the health of the retina and the proper
functioning of the photoreceptors. The RPE is rich in melanosomes, which contain the pigment …

… Scatterplots of FAD τ m versus redox ratio and NADH τ m versus FAD τ m allow separation
of triple-… Neither NADH τ m nor FAD τ m correlated with the glycolytic index or the redox ratio (…