The Esx secretion pathway is conserved across Gram-positive bacteria. Esx-1, the best-characterized
system, is required for virulence of Mycobacterium tuberculosis, although its …

Peptidoglycan (PG) is an essential component of the bacterial cell wall. Although
experiments with organisms in vitro have yielded a wealth of information on PG synthesis and …

Fluorescent probes designed for activation by bioorthogonal chemistry have enabled the
visualization of biomolecules in living systems. Such activatable probes with near-infrared (NIR…

Mycobacteria are surrounded by a complex multilayered envelope and elongate at the poles.
The principles that organize the coordinated addition of chemically diverse cell wall layers …

Mycobacteria, including the pathogen Mycobacterium tuberculosis, use the non-mammalian
disaccharide trehalose as a precursor for essential cell-wall glycolipids and other …

The cell surface is the essential interface between a bacterium and its surroundings.
Composed primarily of molecules that are not directly genetically encoded, this highly dynamic …

10.7554/eLife.37243.001 Rod-shaped mycobacteria expand from their poles, yet d-amino
acid probes label cell wall peptidoglycan in this genus at both the poles and sidewall. We …

Mycobacteria have a distinctive glycolipid-rich outer membrane, the mycomembrane, which
is a critical target for tuberculosis drug development. However, proteins that associate with …

The type VII secretion systems are conserved across mycobacterial species and in many
Gram-positive bacteria. While the well-characterized Esx-1 pathway is required for the …

Bacteria are able to adapt to dramatically different microenvironments, but in many organisms,
the signaling pathways, transcriptional programs, and downstream physiological changes …