The deposition of proteins in the form of amyloid fibrils and plaques is the characteristic feature
of more than 20 degenerative conditions affecting either the central nervous system or a …

Selective autophagy has emerged as a major quality control pathway that surgically removes
damaged or unwanted macromolecules to maintain cellular health. Defects in selective …

The data reported in the past 5 years have highlighted new aspects of protein misfolding
and aggregation. Firstly, it appears that protein aggregation may be a generic property of …

Eukaryotes have evolved various quality control mechanisms to promote proteostasis in the
endoplasmic reticulum (ER). Selective removal of certain ER domains via autophagy (…

A range of human degenerative conditions, including Alzheimer's disease, light-chain
amyloidosis and the spongiform encephalopathies, is associated with the deposition in tissue of …

We have been able to convert a small α/β protein, acylphosphatase, from its soluble and
native form into insoluble amyloid fibrils of the type observed in a range of pathological …

In order for any biological system to function effectively, it is essential to avoid the inherent
tendency of proteins to aggregate and form potentially harmful deposits 1 , 2 , 3 , 4 . In each of …

Background The clinical benefit of preventive eradication of unruptured brain arteriovenous
malformations remains uncertain. A Randomised trial of Unruptured Brain Arteriovenous …

UFMylation involves the covalent modification of substrate proteins with UFM1 (Ubiquitin‐fold
modifier 1) and is important for maintaining ER homeostasis. Stalled translation triggers …

The aberrant assembly of peptides and proteins into fibrillar aggregates proceeds through
oligomeric intermediates that are thought to be the primary pathogenic species in many …