The dose makes the poison: nutritional overload determines the life traits of blood-feeding arthropods

M Sterkel, JHM Oliveira, V Bottino-Rojas… - Trends in …, 2017 - cell.com
Vertebrate blood composition is heavily biased towards proteins, and hemoglobin, which is
a hemeprotein, is by far the most abundant protein. Typically, hematophagous insects ingest …

Genome of Rhodnius prolixus, an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection

…, M Souza-Gomes, M Sterkel… - Proceedings of the …, 2015 - National Acad Sciences
Rhodnius prolixus not only has served as a model organism for the study of insect physiology,
but also is a major vector of Chagas disease, an illness that affects approximately seven …

Comparing treatment intensities of tactile-thermal application

…, K Dong, MT Rau, TE Prescott, AM Lloyd, MT Sterkel… - Dysphagia, 1998 - Springer
The purpose of this study was to investigate the relationships of four intensities of tactile-thermal
application (TTA) to changes in duration of stage transition (DST) and performance on a …

Scaling properties of the tunneling field effect transistor (TFET): Device and circuit

…, J Fischer, M Fulde, A Bargagli-Stoffi, M Sterkel… - Solid-state …, 2006 - Elsevier
The scaling properties of the tunneling field effect transistor (TFET) are shown using standard
130nm, 90nm, and 65nm CMOS process flows. For the different technology nodes the …

Neuropeptide precursor gene discovery in the Chagas disease vector Rhodnius prolixus

S Ons, M Sterkel, L Diambra, H Urlaub… - Insect molecular …, 2011 - Wiley Online Library
We show a straightforward workflow combining homology search in Rhodnius prolixus genome
sequence with cloning by rapid amplification of cDNA ends and mass spectrometry. We …

[PDF][PDF] Tyrosine detoxification is an essential trait in the life history of blood-feeding arthropods

M Sterkel, HD Perdomo, MG Guizzo, ABF Barletta… - Current Biology, 2016 - cell.com
Sterkel et al. show that blood digestion by blood-sucking insects produces toxic amounts
of tyrosine, and that detoxification of an excess of this amino acid is an adaptation to a blood-…

Identification of G protein coupled receptors for opsines and neurohormones in Rhodnius prolixus. Genomic and transcriptomic analysis

S Ons, A Lavore, M Sterkel, JP Wulff, I Sierra… - Insect biochemistry and …, 2016 - Elsevier
The importance of Chagas disease motivated the scientific effort to obtain the complete
genomic sequence of the vector species Rhodnius prolixus, this information is also relevant to …

Identification of a point mutation associated with pyrethroid resistance in the para-type sodium channel of Triatoma infestans, a vector of Chagas' disease

J Fabro, M Sterkel, N Capriotti… - Infection, Genetics and …, 2012 - Elsevier
… Amino acid residue numbers are indicated using the sodium channel of M. domestica as a
M indicates the position of the standard size marker, in which the lower five bands are 100, …

Orcokinin neuropeptides regulate ecdysis in the hemimetabolous insect Rhodnius prolixus

JP Wulff, I Sierra, M Sterkel, M Holtof… - Insect biochemistry and …, 2017 - Elsevier
… In order to quantify the ecdysteroid levels, a serial dilution (ranging from 1028 M to 10212
M) of 20E was placed on each 96-well plate. Results were determined by comparison with …

OKB, a novel family of brain-gut neuropeptides from insects

M Sterkel, PL Oliveira, H Urlaub… - Insect biochemistry and …, 2012 - Elsevier
… Spectra in MS were recorded between 600 and 4000 m/z. Job-wide interpretation of the
MS data allowed the 15 highest peptides in intensity (with signal to noise ratios ≥30) for …