User profiles for M. Suarez-Diez

Maria Suarez-Diez

Systems and Synthetic Biology Wageningen UR
Verified email at wur.nl
Cited by 3244

Degenerate target sites mediate rapid primed CRISPR adaptation

…, MJH Gerritzen, M Suárez-Diez… - Proceedings of the …, 2014 - National Acad Sciences
Prokaryotes encode adaptive immune systems, called CRISPR-Cas (clustered regularly
interspaced short palindromic repeats–CRISPR associated), to provide resistance against …

[HTML][HTML] Regulation of Three Virulence Strategies of Mycobacterium tuberculosis: A Success Story

…, VAP Martins dos Santos, M Suarez-Diez - International journal of …, 2018 - mdpi.com
Tuberculosis remains one of the deadliest diseases. Emergence of drug-resistant and
multidrug-resistant M. tuberculosis strains makes treating tuberculosis increasingly challenging. In …

[HTML][HTML] Systems-level modeling of mycobacterial metabolism for the identification of new (multi-) drug targets

RA Rienksma, M Suarez-Diez, L Spina… - Seminars in …, 2014 - Elsevier
Abstract Systems-level metabolic network reconstructions and the derived constraint-based (CB)
mathematical models are efficient tools to explore bacterial metabolism. Approximately …

Analysis of the microbial gene landscape and transcriptome for aromatic pollutants and alkane degradation using a novel internally calibrated microarray system

…, R Geffers, M SuárezDiez… - Environmental …, 2013 - Wiley Online Library
Despite various efforts to develop tools to detect and compare the catabolic potential and
activity for pollutant degradation in environmental samples, there is still a need for an open‐…

Genome-Scale Model and Omics Analysis of Metabolic Capacities of Akkermansia muciniphila Reveal a Preferential Mucin-Degrading Lifestyle

N Ottman, M Davids, M Suarez-Diez… - Applied and …, 2017 - Am Soc Microbiol
The composition and activity of the microbiota in the human gastrointestinal tract are primarily
shaped by nutrients derived from either food or the host. Bacteria colonizing the mucus …

[HTML][HTML] Understanding the antimicrobial mechanism of TiO2-based nanocomposite films in a pathogenic bacterium

…, M Fernández-García, M Ferrer - Scientific reports, 2014 - nature.com
Titania (TiO 2 )-based nanocomposites subjected to light excitation are remarkably effective
in eliciting microbial death. However, the mechanism by which these materials induce …

[PDF][PDF] Cas3-derived target DNA degradation fragments fuel primed CRISPR adaptation

…, WR Miellet, M Klein, M Depken, M Suarez-Diez… - Molecular cell, 2016 - cell.com
Prokaryotes use a mechanism called priming to update their CRISPR immunological memory
to rapidly counter revisiting, mutated viruses, and plasmids. Here we have determined how …

A bacterial sulfoglycosidase highlights mucin O-glycan breakdown in the gut ecosystem

…, J Hirose, M Suarez-Diez, M Nishiyama… - Nature Chemical …, 2023 - nature.com
Mucinolytic bacteria modulate host–microbiota symbiosis and dysbiosis through their ability
to degrade mucin O-glycans. However, how and to what extent bacterial enzymes are …

[HTML][HTML] Comprehensive insights into transcriptional adaptation of intracellular mycobacteria by microbe-enriched dual RNA sequencing

RA Rienksma, M Suarez-Diez, HJ Mollenkopf… - BMC genomics, 2015 - Springer
Background The human pathogen Mycobacterium tuberculosis has the capacity to escape
eradication by professional phagocytes. During infection, M. tuberculosis resists the harsh …

[HTML][HTML] The effect of prebiotic fortified infant formulas on microbiota composition and dynamics in early life

K Borewicz, M Suarez-Diez, C Hechler, R Beijers… - Scientific reports, 2019 - nature.com
Gastrointestinal (GI) microbiota composition differs between breastfed and formula-fed
infants. Today’s infant formulas are often fortified with prebiotics to better mimic properties of …