… Unlike all other studies, Takasato specified PPS into IM in the presence of FGF9 and not
via the addition of BMP or activin/nodal signalling. This gave rise to a strongly PAX2 + LHX1 + …

The human kidney contains up to 2 million epithelial nephrons responsible for blood filtration.
Regenerating the kidney requires the induction of the more than 20 distinct cell types …

With the prevalence of end-stage renal disease rising 8% per annum globally 1 , there is an
urgent need for renal regenerative strategies. The kidney is a mesodermal organ that …

Human pluripotent stem cell (hPSC)-derived kidney organoids may facilitate disease modeling
and the generation of tissue for renal replacement. Long-term application, however, will …

The human kidney develops from four progenitor populations—nephron progenitors,
ureteric epithelial progenitors, renal interstitial progenitors and endothelial progenitors—resulting …

Mutations in SALL4, the human homolog of the Drosophilahomeotic gene spalt (sal), cause
the autosomal dominant disorder known as Okihiro syndrome. In this study, we show that a …

The treatment of renal failure has seen little change in the past 70 years. Patients with end-stage
renal disease (ESRD) are treated with renal replacement therapy, including dialysis or …

Directed differentiation of human pluripotent stem cells (hPSCs) can provide us any required
tissue/cell types by recapitulating the development in vitro. The kidney is one of the most …

The utility of human pluripotent stem cell–derived kidney organoids relies implicitly on the
robustness and transferability of the protocol. Here we analyze the sources of transcriptional …

Renal stem or progenitor cells with a multilineage differentiation potential remain to be
isolated, and the differentiation mechanism of these cell types in kidney development or …