The modalities of gametogenesis differ markedly between sexes. Female are born with a
definitive reserve of oocytes whose size is crucial to ensure fertility. Male fertility, in contrast, …

TRIM24 (TIF1α), TRIM28 (TIF1β), and TRIM33 (TIF1γ) are three related cofactors belonging
to the tripartite motif superfamily that interact with distinct transcription factors. TRIM24 …

To investigate the role of retinoid X receptors (RXRs) in epidermal homeostasis, we generated
RXRαβ ep-/- somatic mutants in which both RXRα and RXRβ are selectively ablated in …

All-trans retinoic acid (atRA), the active metabolite of vitamin A, plays critical functions in
spermatogenesis, a complex, highly organized and regulated process comprising three phases. …

Hepatocellular carcinoma (HCC) is a major cause of death worldwide. Here, we provide
evidence that the ligand-dependent nuclear receptor co-regulator Trim24 (also known as Tif1α) …

Friedreich’s ataxia (FRDA) is a recessive neurodegenerative disorder commonly associated
with hypertrophic cardiomyopathy. FRDA is due to expanded GAA repeats within the first …

Infertility is a global healthcare problem, and despite long years of assisted reproductive
activities, a significant number of cases remain idiopathic. Our currently restricted understanding …

Studies of prostate cancer pathogenesis and development of new therapies have been
hampered by a lack of appropriate mouse models. We have generated PSA-Cre-ER T2 mice that …

Human induced pluripotent stem cells (hiPSCs) are a most appealing source for cell replacement
therapy in acute brain lesions. We evaluated the potential of hiPSC therapy in stroke …

All-trans retinoic acid (ATRA) is instrumental to male germ cell differentiation, but its mechanism
of action remains elusive. To address this question, we have analyzed the phenotypes …