The combinatorial assembly of protein complexes is at the heart of chromatin biology. Lysine
demethylase LSD1(KDM1A)/CoREST beautifully exemplifies this concept. The active site of …

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a survival rate
less than 5%. Multiple chemotherapeutic drugs have been tested to improve patient prognosis…

The unfolded protein response (UPR) is activated in pancreatic pathologies and suggested
as a target for therapeutic intervention. In this study, we examined activating transcription …

A quick and efficient synthesis and the biological evaluation of promising antitumor-antibiotics
proximicins A, B and C are reported. The characteristic repetitive unit of these molecules, …

Chronic liver diseases comprise a broad spectrum of burdensome diseases that still lack
effective pharmacological therapies. Our research group focuses on fibrosis, which is a major …

Pancreatitis is a debilitating disease involving inflammation and fibrosis of the exocrine
pancreas. Recurrent or chronic forms of pancreatitis are a significant risk factor for pancreatic …

Cyclopropylamines, inhibitors of monoamine oxidases ( MAO ) and lysine‐specific
demethylase ( LSD 1), provide a useful structural scaffold for the design of mechanism‐based …

Background Castrate resistant prostate cancer (CRPC) is often driven by constitutively
active forms of the androgen receptor such as the V7 splice variant (AR-V7) and commonly …

Lysine specific demethylase-1 (LSD1/KDM1A) in complex with its corepressor protein
CoREST is a promising target for epigenetic drugs. No therapeutic that targets LSD1/CoREST, …

We report a series of tranylcypromine analogues containing a fluorine in the cyclopropyl ring.
A number of compounds with additional m- or p-substitution of the aryl ring were …