Clinical evidence supports a role for the extracellular matrix (ECM) in cancer risk and prognosis
across multiple tumor types, and numerous studies have demonstrated that individual …

10.7554/eLife.42144.001 The sarcomere is the contractile unit within cardiomyocytes driving
heart muscle contraction. We sought to test the mechanisms regulating actin and myosin …

High-grade serous ovarian cancer (HGSOC) is the most common and deadly subtype of
ovarian cancer as it is commonly diagnosed after substantial metastasis has already occurred. …

One of the first morphogenetic events in the vertebrate brain is the formation of the highly
conserved midbrain–hindbrain boundary (MHB). Specific cell shape changes occur at the point …

Recent evidence supports the fimbriae of the fallopian tube as one origin site for high-grade
serous ovarian cancer (HGSOC). The progression of many solid tumors is accompanied by …

10.7554/eLife.26002.001 Although microtubules are known for dynamic instability, the
dynamicity is considered to be tightly controlled to support a variety of cellular processes. Yet …

The folding of epithelial tissues is crucial for development of three-dimensional structure
and function. Understanding this process can assist in determining the etiology of …

Multiplexed immunofluorescent (IF) techniques enable the detection of multiple antigens
within the same sample and are therefore useful in situations where samples are rare or small …

The sarcomere is the basic contractile unit within cardiomyocytes driving heart muscle
contraction. We sought to test the mechanisms regulating thin (ie, actin) and thick (ie, myosin) …

The microtubule cytoskeletal system is integral to diverse cellular processes. Although
microtubules are known for dynamic instability, the system is tightly controlled in typical …