Motile multiciliated cells (MCCs) have critical roles in respiratory health and disease and
are essential for cleaning inhaled pollutants and pathogens from airways. Despite their …

Mdm2 is the key negative regulator of the tumour suppressor p53, making it an attractive target
for anti-cancer drug design. We recently identified a new role of Mdm2 in gene repression …

The MDM2 oncoprotein ubiquitinates and antagonizes p53 but may also carry out p53-independent
functions. Here we report that MDM2 is required for the efficient generation of …

p53 induces cell death upon DNA damage, but this may not confer all of its tumor suppressor
activity. We report that p53 activation enhances the processivity of DNA replication, as …

… Simultaneous inhibition of Mdm2 and Wip1 enhanced cell senescence and G2/M accumulation.
Taken together, the inhibition of Wip1 might fortify p53-mediated tumor suppression by …

Background T-DXd (Enhertu ® ) is an FDA-approved antibody-drug conjugate (ADC)
targeting HER2. T-DXd has shown anti-tumor activity, not only in patients with HER2-…

… [Au2Ni2(penicillaminato)4]2": Birker, PJ M. W. L.; Verschoor, GC Inorg. … Markus
Wienken Bernhard Lippert* … (14) Nakamura, A.; Aotake, M.; Otsuka, S. J. Am. …

Motile cilia serve vital functions in development, homeostasis, and regeneration. We
recently demonstrated that TAp73 is an essential transcriptional regulator of respiratory …

… in this work, ci'i- [(NH3)2Pt( 1 -MeU)H20]N03, prepared from «>(NH3)2Pt( 1 -MeU)· 20 and
AgNQ3 in situ, was mixed with 1 equiv of achisH3 with the pH adjustedto 7 by means of 0.1 M …

The pathology of inclusion body myositis (IBM) involves an inflammatory response and β-amyloid
deposits in muscle fibres. It is believed that MAP kinases such as the ERK signalling …