Neural stem cell numbers fall rapidly in the hippocampus of juvenile mice but stabilize during
adulthood, ensuring lifelong hippocampal neurogenesis. We show that this stabilization of …

Neurotrophins are involved in many crucial cellular functions, including neurite outgrowth,
synapse formation, and plasticity. Although these events have long been known, the …

Although it was originally characterized as a constituent of focal adhesions in fibroblasts,
focal adhesion kinase ( FAK ) is now considered to be not only a mediator of adhesion …

10.7554/eLife.48561.001 Quiescence is essential for the long-term maintenance of adult
stem cells but how stem cells maintain quiescence is poorly understood. Here, we show that …

Neural stem cell numbers fall rapidly in the hippocampus of juvenile mice but stabilise during
adulthood, ensuring lifelong hippocampal neurogenesis. We show that this reduction in …

The neurotrophin β-nerve growth factor (NGF) has been described as an important mediator
of seminal plasma-induced ovulation in reflexive ovulators like camelids, but this action has …

Ack1 (activated Cdc42-associated tyrosine kinase) is a non-receptor tyrosine kinase that is
highly expressed in brain. This kinase contains several protein-protein interaction domains …

Quiescence is essential for the long-term maintenance of adult stem cells and tissue
homeostasis. However, how stem cells maintain quiescence is still poorly understood. Here we …

Pathogenic variants of the NOD2 (nucleotide-binding oligomerization domain containing
protein 2) gene demonstrate the strongest genetic association to Crohn’s inflammatory bowel …

Background Pathogenic variants of the NOD2 (nucleotide-binding oligomerization domain
containing protein 2) gene demonstrate the strongest genetic association to Crohn’s …