Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates
ML Arotcarena, S Dovero, A Prigent, M Bourdenx… - Brain, 2020 - academic.oup.com
In Parkinson’s disease, synucleinopathy is hypothesized to spread from the enteric nervous
system, via the vagus nerve, to the CNS. Here, we compare, in baboon monkeys, the …
system, via the vagus nerve, to the CNS. Here, we compare, in baboon monkeys, the …
[HTML][HTML] Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling
…, C Paviolo, E Doudnikoff, ML Arotcarena… - Nature …, 2020 - nature.com
In recent years, exploration of the brain extracellular space (ECS) has made remarkable
progress, including nanoscopic characterizations. However, whether ECS precise conformation …
progress, including nanoscopic characterizations. However, whether ECS precise conformation …
[HTML][HTML] Autophagy in synucleinopathy: the overwhelmed and defective machinery
ML Arotcarena, M Teil, B Dehay - Cells, 2019 - mdpi.com
Alpha-synuclein positive-intracytoplasmic inclusions are the common denominators of the
synucleinopathies present as Lewy bodies in Parkinson’s disease, dementia with Lewy bodies…
synucleinopathies present as Lewy bodies in Parkinson’s disease, dementia with Lewy bodies…
[HTML][HTML] Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
ML Arotcarena, M Bourdenx, N Dutheil, ML Thiolat… - JCI insight, 2019 - ncbi.nlm.nih.gov
The synucleinopathies Parkinson’s disease (PD) and Multiple system atrophy (MSA)—characterized
by α-synuclein intracytoplasmic inclusions into, respectively, neurons and …
by α-synuclein intracytoplasmic inclusions into, respectively, neurons and …
[HTML][HTML] Monitoring α-synuclein aggregation
J Estaun-Panzano, ML Arotcarena, E Bezard - Neurobiology of disease, 2023 - Elsevier
Synucleinopathies, including Parkinson's disease (PD), dementia with Lewy Bodies (DLB),
and multiple system atrophy (MSA), are characterized by the misfolding and subsequent …
and multiple system atrophy (MSA), are characterized by the misfolding and subsequent …
[HTML][HTML] Targeting α-synuclein for PD therapeutics: a pursuit on all fronts
M Teil, ML Arotcarena, E Faggiani, F Laferriere… - Biomolecules, 2020 - mdpi.com
Parkinson’s Disease (PD) is characterized both by the loss of dopaminergic neurons in the
substantia nigra and the presence of cytoplasmic inclusions called Lewy Bodies. These Lewy …
substantia nigra and the presence of cytoplasmic inclusions called Lewy Bodies. These Lewy …
Acidic nanoparticles protect against α‐synuclein‐induced neurodegeneration through the restoration of lysosomal function
ML Arotcarena, FN Soria, A Cunha, E Doudnikoff… - Aging …, 2022 - Wiley Online Library
Parkinson's disease (PD) is an age‐related neurodegenerative disorder characterized by the
loss of dopaminergic neurons in the substantia nigra, associated with the accumulation of …
loss of dopaminergic neurons in the substantia nigra, associated with the accumulation of …
[HTML][HTML] Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain
M Teil, S Dovero, M Bourdenx, ML Arotcarena… - npj Parkinson's …, 2023 - nature.com
Aggregation of α-synuclein (α-syn) is the cornerstone of neurodegenerative diseases termed
synucleinopathies, which include Parkinson’s Disease (PD), Dementia with Lewy Bodies (…
synucleinopathies, which include Parkinson’s Disease (PD), Dementia with Lewy Bodies (…
Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates
Dopaminergic neuronal cell death, associated with intracellular α-synuclein (α-syn)–rich
protein aggregates [termed “Lewy bodies” (LBs)], is a well-established characteristic of …
protein aggregates [termed “Lewy bodies” (LBs)], is a well-established characteristic of …
Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology
M Teil, S Dovero, M Bourdenx, ML Arotcarena… - Brain, 2022 - academic.oup.com
Synucleinopathies encompass several neurodegenerative diseases, which include Parkinson's
disease, dementia with Lewy bodies and multiple system atrophy. These diseases are …
disease, dementia with Lewy bodies and multiple system atrophy. These diseases are …