Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function

…, MD Norenberg, D Nutt, A Weizman, MR Zhang… - Trends in …, 2006 - cell.com
The peripheral-type benzodiazepine receptor or recognition site (PBR) is a widely distributed
transmembrane protein that is located mainly in the outer mitochondrial membrane. The …

[PDF][PDF] Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls

…, T Suhara, H Shinotoh, B Ji, J Maeda, MR Zhang… - Neuron, 2013 - cell.com
Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms
of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have …

[HTML][HTML] Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy

K Hu, L Xie, Y Zhang, M Hanyu, Z Yang… - Nature …, 2020 - nature.com
The use of photothermal agents (PTAs) in cancer photothermal therapy (PTT) has shown
promising results in clinical studies. The rapid degradation of PTAs may address safety …

[HTML][HTML] Peptide-based nanomaterials: Self-assembly, properties and applications

T Li, XM Lu, MR Zhang, K Hu, Z Li - Bioactive Materials, 2022 - Elsevier
Peptide-based materials that have diverse structures and functionalities are an important type
of biomaterials. In former times, peptide-based nanomaterials with excellent stability were …

[PDF][PDF] High-contrast in vivo imaging of tau pathologies in Alzheimer's and non-Alzheimer's disease tauopathies

…, Y Kimura, M Ichise, Y Tomita, MR Zhang… - Neuron, 2021 - cell.com
A panel of radiochemicals has enabled in vivo positron emission tomography (PET) of tau
pathologies in Alzheimer's disease (AD), although sensitive detection of frontotemporal lobar …

Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies

…, JC Van Swieten, A Nordberg, T Suhara, MR Zhang… - Brain, 2017 - academic.oup.com
Diverse neurodegenerative disorders are characterized by deposition of tau fibrils composed
of conformers (ie strains) unique to each illness. The development of tau imaging agents …

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

…, K Kumata, C Seki, M Ono, M Shimojo, MR Zhang… - Nature …, 2020 - nature.com
The chemogenetic technology designer receptors exclusively activated by designer drugs (DREADDs)
afford remotely reversible control of cellular signaling, neuronal activity and …

Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other …

…, M Ono, T Okauchi, M Inaji, MR Zhang… - Journal of …, 2008 - Soc Neuroscience
We demonstrate the significance of peripheral benzodiazepine receptor (PBR) imaging in
living mouse models of Alzheimer's disease (AD) as biomarkers and functional signatures of …

[HTML][HTML] Recent developments on PET radiotracers for TSPO and their applications in neuroimaging

L Zhang, K Hu, T Shao, L Hou, S Zhang, W Ye… - … Pharmaceutica Sinica B, 2021 - Elsevier
… Author links open overlay panel Lingling Zhang a b † , Kuan Hu c † , Tuo Shao d , Lu
Hou a , Shaojuan Zhang a , Weijian Ye a , Lee Josephson d , Jeffrey H. Meyer e , Ming-Rong …

Boron agents for neutron capture therapy

K Hu, Z Yang, L Zhang, L Xie, L Wang, H Xu… - Coordination Chemistry …, 2020 - Elsevier
Boron neutron capture therapy (BNCT) is a potential cancer radiotherapeutic modality, which
takes advantage of the neutron capture response that occurs when boron ( 10 B) is struck …