Males with X-linked severe combined immunodeficiency (XSCID) have defects in the common
cytokine receptor γ chain (γ c ) gene that encodes a shared, essential component of the …

Spatiotemporal aspects of filovirus entry and release are poorly understood. Lipid rafts act as
functional platforms for multiple cellular signaling and trafficking processes. Here, we report …

Ebola virus (EBOV) and Marburg virus (MARV) cause rapidly progressive hemorrhagic fever
with high mortality and may possess specialized mechanisms to evade immune destruction. …

We have cloned cDNAs corresponding to the human interleukin 13 receptor α chain (IL-13Rα).
The protein has 76% homology to murine IL-13Rα, with 95% amino acid identity in the …

Background. Currently, there are no licensed vaccines or therapeutics for the prevention or
treatment of infection by the highly lethal filoviruses, Ebola virus (EBOV) and Marburg virus (…

The filovirus Ebola causes hemorrhagic fever with 70–80% human mortality. High case-fatality
rates, as well as known aerosol infectivity, make Ebola virus a potential global health …

The drivers of critical coronavirus disease 2019 (COVID-19) remain unknown. Given major
confounding factors such as age and comorbidities, true mediators of this condition have …

The matrix protein VP40 plays a critical role in Ebola virus assembly and budding, a process
that utilizes specialized membrane domains known as lipid rafts. Previous studies with …

Antibodies are promising post-exposure therapies against emerging viruses, but which
antibody features and in vitro assays best forecast protection are unclear. Our international …

The serine-threonine kinase Akt/PKB is activated downstream of phosphatidylinositol 3-kinase
in response to several growth factor stimuli and has been implicated in the promotion of …