User profiles for M.R. Betts
Michael R. BettsProfessor, University of Pennsylvania Verified email at mail.med.upenn.edu Cited by 33781 |
Human circulating and tissue-resident memory CD8+ T cells
Our current knowledge of human memory CD8 + T cells is derived largely from studies of the
intravascular space. However, emerging data are starting to challenge some of the dogmas …
intravascular space. However, emerging data are starting to challenge some of the dogmas …
Recommendations for measuring HIV reservoir size in cure-directed clinical trials
Therapeutic strategies are being clinically tested either to eradicate latent HIV reservoirs or
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
INTRODUCTION Many patients with coronavirus disease 2019 (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with severe …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with severe …
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern
…, UPenn COVID Processing Unit‡, I Frank, MR Betts… - Science, 2021 - science.org
INTRODUCTION Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA
vaccines are highly effective at preventing infection and especially severe disease. However, …
vaccines are highly effective at preventing infection and especially severe disease. However, …
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
Establishing a CD8 + T cell–mediated immune correlate of protection in HIV disease is crucial
to the development of vaccines designed to generate cell-mediated immunity. Historically, …
to the development of vaccines designed to generate cell-mediated immunity. Historically, …
[HTML][HTML] Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection
G Makedonas, MR Betts - Springer seminars in immunopathology, 2006 - Springer
More than 25 million people have died of AIDS as a result of infection with the human
immunodeficiency virus (HIV), and between 36 and 45 million individuals are living with the virus. …
immunodeficiency virus (HIV), and between 36 and 45 million individuals are living with the virus. …
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
T cell exhaustion often occurs during chronic infection and prevents optimal viral control. The
molecular pathways involved in T cell exhaustion remain poorly understood. Here we show …
molecular pathways involved in T cell exhaustion remain poorly understood. Here we show …
Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
MR Betts, JM Brenchley, DA Price, SC De Rosa… - Journal of …, 2003 - Elsevier
Flow cytometric detection of antigen-specific CD8+ T cells has previously been limited to
MHC-class I tetramer staining or intracellular cytokine production, neither of which measure the …
MHC-class I tetramer staining or intracellular cytokine production, neither of which measure the …
Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination
…, S Long, K D'Andrea, JT Hamilton, MR Betts… - Science …, 2021 - science.org
mRNA vaccines for SARS-CoV-2 have been authorized for emergency use. Despite their
efficacy in clinical trials, data on mRNA vaccine–induced immune responses are mostly limited …
efficacy in clinical trials, data on mRNA vaccine–induced immune responses are mostly limited …
HIV preferentially infects HIV-specific CD4+ T cells
DC Douek, JM Brenchley, MR Betts, DR Ambrozak… - Nature, 2002 - nature.com
HIV infection is associated with the progressive loss of CD4 + T cells through their destruction
or decreased production 1 , 2 . A central, yet unresolved issue of HIV disease is the …
or decreased production 1 , 2 . A central, yet unresolved issue of HIV disease is the …