User profiles for M.R. Betts

Michael R. Betts

Professor, University of Pennsylvania
Verified email at mail.med.upenn.edu
Cited by 33781

Human circulating and tissue-resident memory CD8+ T cells

M Buggert, DA Price, LK Mackay, MR Betts - Nature Immunology, 2023 - nature.com
Our current knowledge of human memory CD8 + T cells is derived largely from studies of the
intravascular space. However, emerging data are starting to challenge some of the dogmas …

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

…, D Hazuda, F Bushman, JD Siliciano, MR Betts… - Nature medicine, 2020 - nature.com
Therapeutic strategies are being clinically tested either to eradicate latent HIV reservoirs or
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

…, LA Vella, UPenn COVID Processing Unit†, MR Betts… - Science, 2020 - science.org
INTRODUCTION Many patients with coronavirus disease 2019 (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with severe …

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

…, UPenn COVID Processing Unit‡, I Frank, MR Betts… - Science, 2021 - science.org
INTRODUCTION Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA
vaccines are highly effective at preventing infection and especially severe disease. However, …

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

MR Betts, MC Nason, SM West, SC De Rosa… - Blood, 2006 - ashpublications.org
Establishing a CD8 + T cell–mediated immune correlate of protection in HIV disease is crucial
to the development of vaccines designed to generate cell-mediated immunity. Historically, …

[HTML][HTML] Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection

G Makedonas, MR Betts - Springer seminars in immunopathology, 2006 - Springer
More than 25 million people have died of AIDS as a result of infection with the human
immunodeficiency virus (HIV), and between 36 and 45 million individuals are living with the virus. …

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

…, T Zou, CJ Workman, A Polley, MR Betts… - Nature …, 2009 - nature.com
T cell exhaustion often occurs during chronic infection and prevents optimal viral control. The
molecular pathways involved in T cell exhaustion remain poorly understood. Here we show …

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

MR Betts, JM Brenchley, DA Price, SC De Rosa… - Journal of …, 2003 - Elsevier
Flow cytometric detection of antigen-specific CD8+ T cells has previously been limited to
MHC-class I tetramer staining or intracellular cytokine production, neither of which measure the …

Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination

…, S Long, K D'Andrea, JT Hamilton, MR Betts… - Science …, 2021 - science.org
mRNA vaccines for SARS-CoV-2 have been authorized for emergency use. Despite their
efficacy in clinical trials, data on mRNA vaccine–induced immune responses are mostly limited …

HIV preferentially infects HIV-specific CD4+ T cells

DC Douek, JM Brenchley, MR Betts, DR Ambrozak… - Nature, 2002 - nature.com
HIV infection is associated with the progressive loss of CD4 + T cells through their destruction
or decreased production 1 , 2 . A central, yet unresolved issue of HIV disease is the …