The orphan nuclear receptors steroidogenic factor-1 and liver receptor homolog-1: structure, regulation, and essential roles in mammalian reproduction

MC Meinsohn, OE Smith, K Bertolin… - Physiological …, 2019 - journals.physiology.org
Nuclear receptors are intracellular proteins that act as transcription factors. Proteins with
classic nuclear receptor domain structure lacking identified signaling ligands are designated …

[PDF][PDF] Compromised SARS-CoV-2-specific placental antibody transfer

…, AA Boatin, LJ Yockey, D Pepin, MC Meinsohn… - Cell, 2021 - cell.com
SARS-CoV-2 infection causes more severe disease in pregnant women compared to age-matched
non-pregnant women. Whether maternal infection causes changes in the transfer of …

Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses

…, KM Pullen, RM De Guzman, MC Meinsohn… - Science translational …, 2021 - science.org
… Mortality and morbidity risk during the perinatal period and infancy is higher in males than
in … throughout pregnancy and in the perinatal period, but the precise mechanistic differences …

Genetically defined syngeneic mouse models of ovarian cancer as tools for the discovery of combination immunotherapy

…, E Hoefsmit, B Assatova, J Casado, MC Meinsohn… - Cancer Discovery, 2021 - AACR
We engineered a panel of murine fallopian tube epithelial cells bearing mutations typical of
HGSC and capable of forming tumors in syngeneic immunocompetent hosts. These models …

Single-cell sequencing reveals suppressive transcriptional programs regulated by MIS/AMH in neonatal ovaries

MC Meinsohn, HD Saatcioglu, L Wei… - Proceedings of the …, 2021 - National Acad Sciences
… While most of the primordial follicles are described as “dormant” or “resting,” the initial
period immediately following their formation is marked by a wave of both atresia and activation, …

[HTML][HTML] Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene

LM Vansandt, MC Meinsohn, P Godin… - Nature …, 2023 - nature.com
… control cats during the post-treatment period (P = 0.045) but … during the post-treatment period
in control females that is not … -treatment period in comparison to the transition period in the …

A single-cell atlas of the cycling murine ovary

ME Morris, MC Meinsohn, M Chauvin, HD Saatcioglu… - Elife, 2022 - elifesciences.org
The estrous cycle is regulated by rhythmic endocrine interactions of the nervous and
reproductive systems, which coordinate the hormonal and ovulatory functions of the ovary. …

Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve

…, OE Smith, MC Meinsohn… - Proceedings of the …, 2023 - National Acad Sciences
… Next, we evaluated the temporal expression of SF-1 and LRH-1 in the wild-type murine ovary
during the period of primordial follicle assembly. There was a substantial increase in Nr5a2 …

Single-cell sequencing of neonatal uterus reveals an Misr2+ endometrial progenitor indispensable for fertility

…, L Zhang, W Samore, N Nagykery, MC Meinsohn… - elife, 2019 - elifesciences.org
… At this time, the uterus is in a critical early period of development. Treating the mice and
rats with MIS protein during their first six days of life eventually caused the Misr2+ cells to die. …

[PDF][PDF] Cancer-associated mesothelial cells are regulated by the anti-Müllerian hormone axis

M Chauvin, MC Meinsohn, S Dasari, P May, S Iyer… - Cell Reports, 2023 - cell.com
Cancer-associated mesothelial cells (CAMCs) in the tumor microenvironment are thought to
promote growth and immune evasion. We find that, in mouse and human ovarian tumors, …