The mechanisms by which physical forces regulate endothelial cells to determine the
complexities of vascular structure and function are enigmatic 1 , 2 , 3 , 4 , 5 . Studies of sensory …

Mammalian biology adapts to physical activity but the molecular mechanisms sensing the
activity remain enigmatic. Recent studies have revealed how Piezo1 protein senses …

Current therapies for common types of cancer such as renal cell cancer are often ineffective
and unspecific, and novel pharmacological targets and approaches are in high demand. …

The publication of the Australasian Creatinine Consensus Working Group's position statements
in 2005 and 2007 resulted in automatic reporting of estimated glomerular filtration rate (…

Two prominent concepts for the sensing of shear stress by endothelium are the PIEZO1
channel as a mediator of mechanically activated calcium ion entry and the PECAM1 cell …

Optimal detection and subsequent risk stratification of people with chronic kidney disease (CKD)
requires simultaneous consideration of both kidney function (glomerular filtration rate […

Background and Purpose The mechanosensitive Piezo1 channel has important roles in
vascular physiology and disease. Yoda1 is a small‐molecule agonist, but the pharmacology of …

Piezo1 is a mechanosensitive cation channel with widespread physiological importance;
however, its role in the heart is poorly understood. Cardiac fibroblasts help preserve …

The concentration of free cytosolic Ca 2+ and the voltage across the plasma membrane are
major determinants of cell function. Ca 2+ -permeable non-selective cationic channels are …

Background and Purpose The protein PIEZO1 forms mechanically activated, calcium‐permeable,
non‐selective cation channels in numerous cell types from several species. Options for …