Background Despite improved diagnostics, pulmonary pathogens in immunocompromised
children frequently evade detection, leading to significant mortality. Therefore, we aimed to …

Metagenomic next-generation sequencing (mNGS) experiments involving small amounts of
nucleic acid input are highly susceptible to erroneous conclusions resulting from …

The burden of meningitis in low-and-middle-income countries remains significant, but the
infectious causes remain largely unknown, impeding institution of evidence-based treatment …

Preparation of high-quality sequencing libraries is a costly and time-consuming component
of metagenomic next generation sequencing (mNGS). While the overall cost of sequencing …

Understanding MEP fate is important because defects in megakaryocyte and erythrocyte
development lead to disease states such as anaemia, thrombocytopenia and leukaemia. MEP …

Lung injury after pediatric allogeneic hematopoietic cell transplantation (HCT) is a common
and disastrous complication that threatens long-term survival. To develop strategies to …

Myocardin-related transcription factor A (MRTFA) is a coactivator of serum response factor, a
transcription factor that participates in several critical cellular functions including cell growth …

Single-cell assays have enriched our understanding of hematopoiesis and, more generally,
stem and progenitor cell biology. However, these single-end-point approaches provide only …

Impaired baseline lung function is associated with mortality after pediatric allogeneic
hematopoietic cell transplantation (HCT), yet limited knowledge of the molecular pathways that …

Lung injury is a major determinant of survival after pediatric hematopoietic cell transplantation
(HCT). A deeper understanding of the relationship between pulmonary microbes, immunity…