A series of novel 2-amino-4-(4-methylpiperazin-1-yl)-1,3,5-triazine derivatives with different
aryl substituents in the 6-position was designed, synthesized and evaluated for histamine H …

Within the constantly growing number of histamine H 4 (H 4 R) receptor ligands there is a
large group of azine derivatives. A series of novel compounds in the group of 4-…

Background The gold nanoparticles (AuNP's) exhibit interesting chemical and physical
properties and for this reason are intensively tested in medicine. However there is a lack of …

The cardiovascular effects of alpha lipoic acid were evaluated in isolated rat hearts exposed
to ischemia–reperfusion injury in vitro. Alpha-lipoic acid raised the level of sulfane sulfur …

During the search for antiarrhythmic agents among amide derivatives of phenytoin,
compound 7 {3-ethyl-1-[2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propyl]-2,4-dioxo-5,5-diphenyl-…

Background The studied compound: 3-chloro-5-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-9H-xanthen-9-one
dihydrochloride (HBK-6) is a new xanthone derivative. In this study we …

The search for drugs with anorectic activity, acting within the adrenergic system has attracted
the interest of researchers. Partial α 2 -adrenoceptor agonists might offer the potential for …

An association between α 1 -adrenoceptor affinities, hERG K + -antagonistic properties and
antiarrhythmic activities for a series of phenylpiperazine derivatives of hydantoin (2a–21a) …

A series of novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids
designed using a structure-based computational approach was synthesized and assayed to …

A series of 1-substituted pyrrolidin-2-one and pyrrolidine derivatives were synthesised and
tested for electrocardiographic, antiarrhythmic, and antihypertensive activity as well as for α 1 …