After a decade of genome-wide association studies (GWASs), fundamental questions in
human genetics, such as the extent of pleiotropy across the genome and variation in genetic …

Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect
millions of people worldwide. Genome-wide association studies have identified 200 …

Single-cell RNA sequencing (scRNA-seq) data allows to create cell type specific transcriptome
profiles. Such profiles can be aligned with genome-wide association studies (GWASs) to …

The study of the genetic underpinnings of inflammatory bowel disease has made great
progress since the identification of NOD2 as a major susceptibility gene. Novel genotyping and …

Anti-tumor necrosis factor alpha (anti-TNF) biologic therapy is a widely used treatment for
rheumatoid arthritis (RA). It is unknown why some RA patients fail to respond adequately to anti…

Background Treatment strategies blocking tumour necrosis factor (anti-TNF) have proven
very successful in patients with rheumatoid arthritis (RA). However, a significant subset of …

Objectives Pharmacogenetic studies of tumour necrosis factor inhibitors (TNFi) response in
patients with rheumatoid arthritis (RA) have largely relied on the changes in complex disease …

Purpose In this study we aimed to establish the genetic cause of a myriad of cardiovascular
defects prevalent in individuals from a genetically isolated population, who were found to …

Rheumatoid arthritis is a disease showing considerable heterogeneity in all its aspects,
including response to therapy. The efficacy of disease-modifying antirheumatic drugs (DMARDs)…

Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory disorder that
affects millions worldwide. Genome-wide association studies (GWAS) have identified 200 IBD-…