Blood outgrowth endothelial cells (BOECs) are important tools when investigating diagnostic
and therapeutic approaches for vascular disease. In this protocol, mononuclear cells are …

To obtain a molecular definition of regulatory T (Treg) cell identity, we performed proteomics
and transcriptomics on various populations of human regulatory and conventional CD4 + T (…

The secretome of cancer and stromal cells generates a microenvironment that contributes to
tumour cell invasion and angiogenesis. Here we compare the secretome of human …

Memory T cells are critical for the immune response to recurring infections. Their
instantaneous reactivity to pathogens is empowered by the persistent expression of cytokine-encoding …

Human neutrophilic granulocytes form the largest pool of innate immune cells for host
defense against bacterial and fungal pathogens. The dynamic changes that accompany the …

Cytotoxic CD8 + T cells can effectively kill target cells by producing cytokines, chemokines,
and granzymes. Expression of these effector molecules is however highly divergent, and …

Platelet-von Willebrand factor (VWF) is stored within α-granules and accounts for ∼20% of
total VWF in platelet-rich plasma. This platelet-VWF pool is distinct from plasma-VWF and is …

BACKGROUND: The uptake and processing of blood coagulation factor VIII (FVIII) by
antigen-presenting cells and the subsequent presentation of FVIII-derived peptides to CD4 + T …

The classical central macrophage found in erythroblastic islands plays an important role in
erythroblast differentiation, proliferation and enucleation in the bone marrow. Convenient …

The endothelial lining of blood vessels is covered with a thin polysaccharide coat called the
glycocalyx. This layer of polysaccharides contains hyaluronan that forms a protective coat on …